Month: November 2021

Safety of 5-Norbornene-2-carbonitrile. In 2019 CIN-COMPUT INFORM NU published article about SIMULATION; PERFORMANCE in [Farra, Sharon L.] Wright State Univ, Coll Nursing & Hlth, 3640 Colonel Glenn Hwy, Dayton, OH 45435 USA; [Gneuhs, Matthew] Cincinnati Childrens Hosp & Med Ctr, Emergency Preparedness & Response, Cincinnati, OH USA; [Hodgson, Eric] Miami Univ, Smale Interact Visualizat Ctr, Coral Gables, FL USA; [Kawosa, Burhan] Wright State Univ, Raj Soin Coll Business, Dayton, OH 45435 USA; [Miller, Elaine T.] Univ Cincinnati, Coll Nursing, Cincinnati, OH 45221 USA; [Simon, Ashley] Cincinnati Childrens Hosp Med Ctr, Neonatal Intens Care Unit, Cincinnati, OH 45229 USA; [Timm, Nathan] Univ Cincinnati, Coll Med, Cincinnati, OH 45221 USA; [Timm, Nathan] Cincinnati Childrens Hosp Med Ctr, Div Emergency Med, Cincinnati, OH 45229 USA; [Hausfeld, Jackie] Cincinnati Childrens Hosp & Med Ctr, Patient Serv Inst, Cincinnati, OH USA in 2019, Cited 22. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4.

Adoption of virtual reality technology may be delayed due to high up-front costs with unknown returns on that investment. In this article, we present a cost analysis of using virtual reality as a training tool. Virtual reality was used to train neonatal intensive care workers in hospital evacuation. A live disaster exercise with mannequins was also conducted that approximated the virtual experience. Comparative costs are presented for the planning, development, and implementation of both interventions. Initially, virtual reality is more expensive, with a cost of $229.79 per participant (total cost $18 617.54 per exercise) for the live drill versus $327.78 (total cost $106 951.14) for virtual reality. When development costs are extrapolated to repeated training over 3 years, however, the virtual exercise becomes less expensive with a cost of $115.43 per participant, while the cost of live exercises remains fixed. The larger initial investment in virtual reality can be spread across a large number of trainees and a longer time period with little additional cost, while each live drill requires additional costs that scale with the number of participants.

Safety of 5-Norbornene-2-carbonitrile. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Farra, SL; Gneuhs, M; Hodgson, E; Kawosa, B; Miller, ET; Simon, A; Timm, N; Hausfeld, J or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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Recently I am researching about METAL-ORGANIC FRAMEWORKS; ABSOLUTE STRUCTURE DETERMINATION; STATIONARY PHASES; ENANTIOMER SEPARATION; RESOLUTION; RECOGNITION; HPLC; SULFOXIDES; CATALYSIS; ISOMERS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21777074, 21775056]; Tianjin Natural Science FoundationNatural Science Foundation of Tianjin [18JCQNJC05700]; Fundamental Research Funds for Central UniversitiesFundamental Research Funds for the Central Universities. SDS of cas: 95-11-4. Published in ELSEVIER in AMSTERDAM ,Authors: Wang, ZM; Yang, CX; Yan, XP. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile

Chiral crystalline sponges (CCSs) are a recent class of chiral porous metal complexes potential in chiral recognition. Here we report the fabrication of polysiloxane OV-1701 incorporated CCS-3S (PSO/CCS-3S) coated capillary column as a novel stationary phase for gas chromatographic separation of diverse race-mates. CCS-3S with the chiral ligand of (S)-mandelic was selected as the model CCS. With the aid of polysiloxane OV-1701, PSO/CCS-3S coated capillary column gave improved resolution, broader enantiomers separation scope and much larger McReynolds constants than CCS-3S coated capillary column. Many racemates that cannot be separated on CCS-3S coated capillary column were well resolved on PSO/CCS-3S coated capillary column. The PSO/CCS-3S coated capillary column also gave wide linear range, low limit of detection, good repeatability and reproducibility, and fine inertness and anti-column bleeding properties for the separation of enantiomers. In addition, the PSO/CCS-3S coated capillary column presented better resolution for the studied racemates than commercial beta-cyclodextrin based Cyclosil B (30 m long x0.32 mm i.d. x 0.25 mu m film thickness), beta-DEX 225 (30 m long x0.25 mm i.d. x 0.25 mu m film thickness) and amino acid based Chirasil L-Val (25 m long x0.25 mm i.d. x 0.12 mu m film thickness) capillary columns. These results indicate the great potential of PSO/CCS-3S coated capillary column in separation of enantiomers. (C) 2019 Elsevier B.V. All rights reserved.

SDS of cas: 95-11-4. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Wang, ZM; Yang, CX; Yan, XP or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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Farra, SL; Gneuhs, M; Hodgson, E; Kawosa, B; Miller, ET; Simon, A; Timm, N; Hausfeld, J in [Farra, Sharon L.] Wright State Univ, Coll Nursing & Hlth, 3640 Colonel Glenn Hwy, Dayton, OH 45435 USA; [Gneuhs, Matthew] Cincinnati Childrens Hosp & Med Ctr, Emergency Preparedness & Response, Cincinnati, OH USA; [Hodgson, Eric] Miami Univ, Smale Interact Visualizat Ctr, Coral Gables, FL USA; [Kawosa, Burhan] Wright State Univ, Raj Soin Coll Business, Dayton, OH 45435 USA; [Miller, Elaine T.] Univ Cincinnati, Coll Nursing, Cincinnati, OH 45221 USA; [Simon, Ashley] Cincinnati Childrens Hosp Med Ctr, Neonatal Intens Care Unit, Cincinnati, OH 45229 USA; [Timm, Nathan] Univ Cincinnati, Coll Med, Cincinnati, OH 45221 USA; [Timm, Nathan] Cincinnati Childrens Hosp Med Ctr, Div Emergency Med, Cincinnati, OH 45229 USA; [Hausfeld, Jackie] Cincinnati Childrens Hosp & Med Ctr, Patient Serv Inst, Cincinnati, OH USA published Comparative Cost of Virtual Reality Training and Live Exercises for Training Hospital Workers for Evacuation in 2019, Cited 22. Category: nitriles-buliding-blocks. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4.

Adoption of virtual reality technology may be delayed due to high up-front costs with unknown returns on that investment. In this article, we present a cost analysis of using virtual reality as a training tool. Virtual reality was used to train neonatal intensive care workers in hospital evacuation. A live disaster exercise with mannequins was also conducted that approximated the virtual experience. Comparative costs are presented for the planning, development, and implementation of both interventions. Initially, virtual reality is more expensive, with a cost of $229.79 per participant (total cost $18 617.54 per exercise) for the live drill versus $327.78 (total cost $106 951.14) for virtual reality. When development costs are extrapolated to repeated training over 3 years, however, the virtual exercise becomes less expensive with a cost of $115.43 per participant, while the cost of live exercises remains fixed. The larger initial investment in virtual reality can be spread across a large number of trainees and a longer time period with little additional cost, while each live drill requires additional costs that scale with the number of participants.

About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Farra, SL; Gneuhs, M; Hodgson, E; Kawosa, B; Miller, ET; Simon, A; Timm, N; Hausfeld, J or concate me.. Category: nitriles-buliding-blocks

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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Alnaimat, AS; Barciela-Alonso, MC; Herbello-Hermelo, P; Dominguez-Gonzalez, R; Bermejo-Barrera, P in [Alnaimat, Ala S.; Carmen Barciela-Alonso, Maria; Herbello-Hermelo, Paloma; Dominguez-Gonzalez, Raquel; Bermejo-Barrera, Pilar] Univ Santiago de Compostela, Dept Analyt Chem Nutr & Bromatol, Fac Chem, Grp Trace Elements Speciat & Spect GETEE,Strateg, Ave Ciencias S-N, Santiago De Compostela 15782, Spain; [Alnaimat, Ala S.] Al Hussein Bin Talal Univ, Coll Sci, Dept Chem, Maan, Jordan published In vitro assessment of major and trace element bioaccessibility in tea samples in 2021, Cited 46. Quality Control of 5-Norbornene-2-carbonitrile. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4.

Bioaccessibility of trace elements (Li, Be, Ti, Ga, Cu, Ag, Hg, Cd, Cs, Pt, Tl, Pb, As, Cr, Co, Ni, V, Se, Sn and Sb) and major elements (Rb, Ba, Al, Fe, Zn, Si, Ca, Mg, Mn, Mo, Sr, P and K) in tea infusions has been assessed using an in vitro dialyzability protocol. Gastric simulation (using pepsin solution) and intestinal simulation (using pancreatin and bile salts) were used to perform the in vitro digestion. ICP-MS, ICP-OES and FAES were used for elements determination in digested tea leaves, their infusions and the dialyzate fractions from tea infusions. Microwaves assisted acid digestion was used for the total element determination in tea leaves, while tea infusions were prepared by brewing tea leaves for 5 min in boiling water. The LODs for elements determined in tea leaves were in the range of 0.11-656 ng g(-1) and 0.02-145.6 mu g g(-1) for trace and major elements, respectively. For elements’ determination in tea infusions, the LODs were ranged between 0.23 and 399.9 ng L-1 for trace elements and 0.2-1248 mu g L-1 for major elements. The LODs for the elements in the dialyzable fraction varied from 0.018 to 142 mu g L-1. The accuracy of the total element determination was evaluated using certified reference materials (Tea Leaves INCT-TL-1 and Rye Grass). The analytical recoveries were also assessed for analyzed elements in digested tea leaves (95-114%) and their infusions (92-115%), showing good recoveries. Among the studied elements, K was the most abundant element in tea leaves and tea infusions in almost all samples, followed by Ca, Mg, and P. Zn, Cs, and K showed the highest dialyzability percentages up to 84%, 76%, and 54%, respectively, followed by Si and Ca and K that show moderate to high dialyzability percentages. The accuracy of the dialysis process was evaluated using a mass-balance study.

Quality Control of 5-Norbornene-2-carbonitrile. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Alnaimat, AS; Barciela-Alonso, MC; Herbello-Hermelo, P; Dominguez-Gonzalez, R; Bermejo-Barrera, P or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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Quality Control of 5-Norbornene-2-carbonitrile. Recently I am researching about LIQUID-PHASE HYDROGENATION; HIGHLY-ACTIVE HYDROGENATION; ORGANIC FRAMEWORK NODES; ASYMMETRIC HYDROGENATION; SELECTIVE HYDROGENATION; CATALYTIC-HYDROGENATION; COMPLEXES; ISOOCTENES; KINETICS; CO, Saw an article supported by the State of Mecklenburg Western Pomerania, the BMBFFederal Ministry of Education & Research (BMBF) [03XP0060]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Pews-Davtyan, A; Scharnagl, FK; Hertrich, MF; Kreyenschulte, C; Bartling, S; Lund, H; Jackstell, R; Beller, M. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile

Catalytic hydrogenation of olefins using noble metal catalysts or pyrophoric RANEY (R) nickel is of high importance in the chemical industry. From the point of view of green and sustainable chemistry, design and development of Earth-abundant, less toxic, and more environmentally friendly catalysts are highly desirable. Herein, we report the convenient preparation of active cobalt catalysts and their application in hydrogenations of a wide range of terminal and internal carbon-carbon double bonds in water under mild conditions. Catalysts are prepared on multi-gram scale by pyrolysis of cobalt acetate and uracil, guanine, adenine or l-tryptophan. The most active material Co-Ura/C-600 showed good productivity in industrially relevant hydrogenation of diisobutene to isooctane and in natural oil hardening.

About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Pews-Davtyan, A; Scharnagl, FK; Hertrich, MF; Kreyenschulte, C; Bartling, S; Lund, H; Jackstell, R; Beller, M or concate me.. Quality Control of 5-Norbornene-2-carbonitrile

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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An article Prevalence of diabetes and pre -diabetes in Greece. Results of the First National Survey of Morbidity and Risk Factors (EMENO) study WOS:000632552500005 published article about CARDIOVASCULAR MORBIDITY; ADULTS; POPULATION; MELLITUS; BURDEN; HEALTH; TRENDS; SAMPLE; EPIDEMIOLOGY; SURVEILLANCE in [Makrilakis, Konstantinos; Ioannidis, Ioannis; Iraklianou, Stella; Raptis, Athanasios; Sotiropoulos, Alexis; Liatis, Stavros] Hellen Diabet Assoc, Athens, Greece; [Makrilakis, Konstantinos; Liatis, Stavros] Natl & Kapodistrian Univ Athens, Med Sch, Dept Propaedeut Internal Med 1, Athens, Greece; [Kalpourtzi, Natasa; Kantzanou, Maria; Touloumi, Giota] Natl & Kapodistrian Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, Athens, Greece; [Ioannidis, Ioannis] Konstantopoulio Hosp, Dept Internal Med 1, Nea Ionia, Greece; [Ioannidis, Ioannis] Konstantopoulio Hosp, Diabet Ctr, Nea Ionia, Greece; [Iraklianou, Stella] Gen Hosp Tzaneio, Dept Internal Med 3, Piraeus, Greece; [Raptis, Athanasios] Natl & Kapodistrian Univ Athens, Med Sch, Attikon Univ Hosp, Dept Propaedeut Internal Med 2,Res Unit, Athens, Greece; [Raptis, Athanasios] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Diabet Ctr, Athens, Greece; [Sotiropoulos, Alexis] Gen Hosp Nikaia Piraeus, Internal Med Dept 3, Nikea, Greece; [Sotiropoulos, Alexis] Gen Hosp Nikaia Piraeus, Diabet Ctr, Nikea, Greece; [Gavana, Magda] Aristotle Univ Thessaloniki, Med Sch, Dept Primary Hlth Care Gen Practice & Hlth Serv R, Thessaloniki, Greece; [Vantarakis, Apostolos] Univ Patras, Med Sch, Publ Hlth, Patras, Greece; [Hadjichristodoulou, Christos] Univ Thessaly, Med Fac, Dept Hyg & Epidemiol, Larisa, Greece; [Chlouverakis, Grigoris] Univ Crete, Sch Med, Lab Biostat, Iraklion, Greece; [Trypsianis, Grigoris] Democritus Univ Thrace, Med Sch, Lab Med Stat, Thrace, Greece; [Voulgari, Paraskevi V.] Univ Ioannina, Med Sch, Dept Internal Med, Ioannina, Greece; [Alamanos, Yannis] Inst Epidemiol Prevent Med & Publ Hlth, Corfu, Greece in 2021, Cited 43. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4. Computed Properties of C8H9N

Aims: To report the results of the first national Health Examination Survey (HES) on the prevalence of diabetes, its pharmacologic treatment and level of control, as well as pre -diabetes in Greece. Methods: Data were derived from the National Survey of Morbidity and Risk Factors (EMENO), in a randomly selected, representative sample of the adult Greek population. Sampling weights were applied to adjust for study design and post-stratification weights to match sample age/sex distribution to the population. Non-response was adjusted by inverse probability weighting. Weighted prevalence estimates are provided. Results: A total of 4393 persons with HbA1c and/or fasting plasma glucose measurements were included. Total diabetes prevalence was 11.9% (95% CI: 10.9-12.9), known diabetes 10.4% (9.5-11.4), and unknown 1.5% (1.1-1.9), with considerable increase in older age groups and no difference between genders. Pre-diabetes prevalence was 12.4% (11.4-13.6). The majority of persons with known diabetes were receiving metformin. Of those with known diabetes (and measured HbA1c), 70.9% were well controlled (HbA1c <7.0%). Conclusions: This first representative national HES showed high prevalence of diabetes in Greece, with low prevalence of unknown diabetes. Pre-diabetes prevalence is also substantial. These results will hopefully enable national authorities develop tailored and efficient strategies for disease prevention and management. Computed Properties of C8H9N. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Makrilakis, K; Kalpourtzi, N; Ioannidis, I; Iraklianou, S; Raptis, A; Sotiropoulos, A; Gavana, M; Vantarakis, A; Kantzanou, M; Hadjichristodoulou, C; Chlouverakis, G; Trypsianis, G; Voulgari, PV; Alamanos, Y; Touloumi, G; Liatis, S or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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Safety of 5-Norbornene-2-carbonitrile. I found the field of Chemistry very interesting. Saw the article Modular Dual-Tasked C-H Methylation via the Catellani Strategy published in 2019, Reprint Addresses Zhou, QH (corresponding author), Wuhan Univ, Engn Res Ctr Organosilicon Cpds & Mat, Sauvage Ctr Mol Sci, Coll Chem & Mol Sci,Minist Educ, Wuhan 430072, Peoples R China.; Zhou, QH (corresponding author), Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China.. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile.

We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and methylating reagent, respectively. Six types of ipso terminations can modularly couple with this ortho C-H methylation to constitute a versatile methylation toolbox for preparing diversified methylated arenes. This toolbox features inexpensive methyl sources, excellent functional-group tolerance, simple reaction procedures, and scalability. Importantly, it can be uneventfully extended to isotope-labeled methylation by switching to the corresponding reagents CD3OTs or (CH3OTs)-C-13. Moreover, this toolbox can be applied to late-stage modification of biorelevant substrates with complete stereoretention. We believe these salient and practical features of our dual-tasked methylation toolbox will be welcomed by academic and industrial researchers.

About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Gao, QW; Shang, Y; Song, FZ; Ye, JX; Liu, ZS; Li, LS; Cheng, HG; Zhou, QH or concate me.. Safety of 5-Norbornene-2-carbonitrile

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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Category: nitriles-buliding-blocks. Authors Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S in KARGER published article about in [Bar-Or, Ruth Lev; Kor, Ariel; Lev-Ran, Shaul] Israel Ctr Addict ICA, Hazoran St 2, IL-4250602 Netanya, Israel; [Bar-Or, Ruth Lev] Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth & Community Med, Jerusalem, Israel; [Kor, Ariel] Interdisciplinary Ctr IDC, Herzliyya, Israel; [Kor, Ariel] Yale Univ, Yale Sch Med, New Haven, CT USA; [Jaljuli, Iman] Tel Aviv Univ, Dept Stat & Operat Res, Tel Aviv, Israel; [Lev-Ran, Shaul] Lev Hasharon Med Ctr, Netanya, Israel; [Lev-Ran, Shaul] Tel Aviv Univ, Dept Psychiat, Sackler Fac Med, Tel Aviv, Israel in , Cited 51. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4

Introduction: Substance use disorders (SUDs) are a leading cause of morbidity and mortality worldwide, having a profound and global impact on health, well-being, safety, and productivity. Although traditionally the prevalence of SUDs in Israel has been estimated to be lower than those in high-income countries, estimates and characteristics of individuals with SUDs in the past decade are lacking. In this work, we explored the prevalence of SUDs among the adult Jewish population in Israel, per different classes of substances across sex, age group, and other sociodemographic factors. Methods: Data from an online representative sample of 4,025 respondents were collected, including the alcohol, smoking, and substance involvement screening test (ASSIST) metric and sociodemographic data. Results: We found that the most common SUDs were alcohol (10.5% [9.5-11.4]), cannabis (9.0% [8.2-9.9]), and sedative (3.6% [3.0-4.2]) use disorders. Alcohol-cannabis (3.2% [2.7-3.7]) and alcohol-sedative (1.04% [0.7-1.35]) were the most prevalent co-occurring SUDs. Among those with cannabis use disorder, the prevalence of alcohol use disorder was found to be 35.3% [30.4-40.2]. The estimated risk for alcohol use disorder was found to be inversely proportional to age, cannabis use disorder increased, peaked, and decreased with age, and that of sedative use disorder increased with age, particularly among women. While older individuals (in the 51-60 years of age group) were at lower risk (OR = 0.5 [0.3, 0.8]) compared to those <20 years of age for alcohol use disorder, they were at increased risk for sedative use disorder (OR = 3.1 [1.2, 9.7]). Conclusions: These findings represent substantially higher rates of SUDs in Israel than those previously reported and should affect resources allocated to addiction prevention and treatment. Further research on the role of gender, age, culture, and ethnicity in the propensity to develop SUDs is necessary for the development of more focused preventive and intervention measures. Focusing on non-Jewish populations in Israel and broadening the scope to include behavioral addictions should be addressed in future studies. Category: nitriles-buliding-blocks. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Bar-Or, RL; Kor, A; Jaljuli, I; Lev-Ran, S or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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In 2019 TOXICOL IN VITRO published article about BOVINE CORNEAL OPACITY; TIME EXPOSURE TEST; HPLC/UPLC-SPECTROPHOTOMETRY; HAZARD IDENTIFICATION; APPLICABILITY DOMAIN; CHEMICALS; ASSAY; VALIDATION in [Alepee, N.] LOreal Res & Innovat, Aulnay Sous Bois, France; [Adriaens, E.] Adriaens Consulting, Aalter, Belgium; [Abo, T.] Kao Corp, Safety Sci Res, Kawasaki, Kanagawa, Japan; [Bagley, D.] Colgate Palmolive Co, Piscataway, NJ USA; [Desprez, B.] Cosmet Europe Personal Care Assoc, Brussels, Belgium; [Hibatallah, J.] Chanel Parfums Beaute, Neuilly Sur Seine, France; [Mewes, K.] Henkel AG & Co KGaA, Dusseldorf, Germany; [Pfannenbecker, U.] Beiersdorf AG, Hamburg, Germany; [Sala, A.] Kao Corp SA, Barcelona, Spain; [Sala, A.] HP Inc, Barcelona, Spain; [Van Rompay, A. R.; Verstraelen, S.] VITO NV Flemish Inst Technol Res, Mol, Belgium; [McNamee, P.] Procter & Gamble Co, Egham, Surrey, England in 2019, Cited 36. The Name is 5-Norbornene-2-carbonitrile. Through research, I have a further understanding and discovery of 95-11-4. Recommanded Product: 5-Norbornene-2-carbonitrile

The focus of Cosmetics Europe’s programme on serious eye damage/eye irritation is on development of testing strategies and defined approaches for identification of ocular effects of chemicals in the context of OECD’s Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation. Cosmetics Europe created a comprehensive database of chemicals for which in vitro data are available with corresponding historical in vivo Draize eye data. This database allowed further exploration of the initially proposed strategies from the CON4EI project and to identify opportunities for refinement. The current analysis focused on the development of a defined approach, applicable to liquid non-surfactant chemicals, neat and in dilution, that can distinguish between the three UN GHS categories (Cat. 1, Cat. 2, and No Cat.). Combining the modified-protocol Short Time Exposure (STE) test method (OECD TG 491 with extension to highly volatile substances) with the Bovine Corneal Opacity and Permeability Laser Light-Based Opacitometer (BCOP LLBO) test method in a Bottom-Up approach identified 81.2% Cat. 1, 56.3% Cat. 2, and 85.3% No. Cat correctly, with an NPV of 96.7% and a PPV of 68.6%. Therefore, the performance of the defined approach was better than the standalone test methods.

Recommanded Product: 5-Norbornene-2-carbonitrile. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Alepee, N; Adriaens, E; Abo, T; Bagley, D; Desprez, B; Hibatallah, J; Mewes, K; Pfannenbecker, U; Sala, A; Van Rompay, AR; Verstraelen, S; McNamee, P or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
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I found the field of Toxicology very interesting. Saw the article Development of a defined approach for eye irritation or serious eye damage for liquids, neat and in dilution, based on cosmetics Europe analysis of in vitro STE and BCOP test methods published in 2019. Recommanded Product: 5-Norbornene-2-carbonitrile, Reprint Addresses Adriaens, E (corresponding author), Adriaens Consulting BVBA, Bellemdorpweg 95, B-9881 Aalter, Belgium.. The CAS is 95-11-4. Through research, I have a further understanding and discovery of 5-Norbornene-2-carbonitrile

The focus of Cosmetics Europe’s programme on serious eye damage/eye irritation is on development of testing strategies and defined approaches for identification of ocular effects of chemicals in the context of OECD’s Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation. Cosmetics Europe created a comprehensive database of chemicals for which in vitro data are available with corresponding historical in vivo Draize eye data. This database allowed further exploration of the initially proposed strategies from the CON4EI project and to identify opportunities for refinement. The current analysis focused on the development of a defined approach, applicable to liquid non-surfactant chemicals, neat and in dilution, that can distinguish between the three UN GHS categories (Cat. 1, Cat. 2, and No Cat.). Combining the modified-protocol Short Time Exposure (STE) test method (OECD TG 491 with extension to highly volatile substances) with the Bovine Corneal Opacity and Permeability Laser Light-Based Opacitometer (BCOP LLBO) test method in a Bottom-Up approach identified 81.2% Cat. 1, 56.3% Cat. 2, and 85.3% No. Cat correctly, with an NPV of 96.7% and a PPV of 68.6%. Therefore, the performance of the defined approach was better than the standalone test methods.

Recommanded Product: 5-Norbornene-2-carbonitrile. About 5-Norbornene-2-carbonitrile, If you have any questions, you can contact Alepee, N; Adriaens, E; Abo, T; Bagley, D; Desprez, B; Hibatallah, J; Mewes, K; Pfannenbecker, U; Sala, A; Van Rompay, AR; Verstraelen, S; McNamee, P or concate me.

Reference:
Patent; Mitsui Chemicals, Inc.; KUMA, Shigetoshi; SAKATA, Michiharu; TOKUNAGA, Kouichi; SHIMAKAWA, Chitoshi; KAKINUMA, Naoyuki; FURUYA, Masayuki; TANAKA, Mamoru; EP2708527; (2014); A1;,
Nitrile – Wikipedia,
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