So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sutar, Suraj M.; Prabhala, Pavankumar; Savanur, Hemantkumar M.; Kalkhambkar, Rajesh G.; Aridoss, Gopalakrishnan; Laali, Kenneth K. researched the compound: 2,4,5-Triphenylimidazole( cas:484-47-9 ).Quality Control of 2,4,5-Triphenylimidazole.They published the article 《Copper-Catalyzed Coupling of Arylethynes and Aryltriazenes to Access Libraries of 1,2-Diketones and Their Efficacy in Synthesis of Triaryloxazoles, Imidazoles and Diaryl-Diazepines》 about this compound( cas:484-47-9 ) in ChemistrySelect. Keywords: diaryl diazepine preparation; diamine diaryl diketone heterocyclization; triaryloxazole preparation; benzylamine diaryl diketone preparation tandem heterocyclization; imidazole preparation; aryl aldehyde diaryl diketone preparation heterocyclization; arylethyne aryltriazene oxidative coupling copper catalyst. We’ll tell you more about this compound (cas:484-47-9).
Libraries of diaryl-1,2-diketones RC6H4C(O)C(O)C6H4R1 (R = H, 3-Me, 4-Cl, 4-Br, etc.; R1 = H, 4-Br, 4-Cl, 4-Me, etc.) were synthesized by oxidative coupling of 1-aryl-ethynes RC6H4CCH with 1-aryl-triazenes R1C6H4N=NR2 (R2 = piperidin-1-yl, morpholin-4-yl, pyrrolidin-1-yl), employing tetramethylguanidinium ionic liquid [TMG][CF3COO] and Cu(OAc)2. The synthesized compounds served as scaffolds for facile one-pot synthesis of diverse libraries of pharmaceutically important heterocycles I (R3 = Ph, 4-chlorophenyl, furan-2-yl, etc.), II (R4 = H, Me, OMe, Cl, Br) and III in ionic liquid solvents. Thus BMIM-ionic liquid/CuI was utilized for the synthesis of triaryl-oxazoles I, [TMG][HSO4]/NH4OAc was used to prepare triaryl-imidazoles II, and [TMG][OAc] was employed for the synthesis of diaryl-diazepines III. Reactions were performed in fresh as well as in recycled ionic liquids The reported methods expand the available protocols for the synthesis of diaryl-1,2-diketones, and enable facile access to pharmaceutically important nitrogen heterocycles I, II and III.
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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts