Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about 2-Chloro-4-nitroimidazole radiosensitizers of hypoxic tumor cells in vivo.Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole.
The transplantable rhabdomyosarcoma in WAG/Rij rats was used to test the in vivo effectiveness of 1-methyl-2-chloro-4-nitroimidazole (P13) and its analog 1-(2-hydroxy-3-methoxypropyl)-2-chloro-4-nitroimidazole (P40) as tumor-cell radiosensitizers after their i.p. administration at low doses. Both compounds administered repeatedly at nontoxic concentrations (70-150 mg/kg body weight) in combination with moderate fractional doses of γ-irradiation (3.7 Gy) enhance the radiation effect on tumors. The local control of tumors on the 210th day in all exptl. groups was higher than in the control ones. In the case of P40 administered at the maximal dose, the increment in local control is significant. The regrowth delay has also been longer after treatment with radiosensitizers. In the course of treatment, no symptoms of neurotoxicity of the compounds were observed The mean body weight of rats during the administration of compounds remained at the level of control rats whose tumors were irradiated only.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Chloro-1-methyl-4-nitroimidazole)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole, illustrating the importance and wide applicability of this compound(4897-25-0).
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts