Dai, Xin; Song, Zhi-Ling; Song, Wenjuan; Zhang, Jiling; Fan, Gao-Chao; Wang, Wei; Luo, Xiliang published the article 《Shell-Switchable SERS Blocking Strategy for Reliable Signal-On SERS Sensing in Living Cells: Detecting an External Target without Affecting the Internal Raman Molecule》. Keywords: SERS Raman spectroscopy.They researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Formula: C5H5NS. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4556-23-4) here.
For SERS anal. in living cells, the inevitable desorption of Raman mol. on the substrate surface is a key challenge. To ensure high stability, SERS systems with Raman mols. protected inside the core-Raman mol.-shell (C-M-S) structures have been designed, but at the expense of sacrificed sensing performances. Here a shell-switchable SERS blocking strategy is developed for the reliable SERS anal. in living cells, relying on the shell blockers to regulate the SERS sensing signal without affecting the internal Raman mols. After several C-M-S structures were studied, the SERS blocking mechanism confirmed that thick shells (Au, Ag, ZnO, and MnO2) can cause a significant reduction in the internal SERS signal by obstructing the penetration of the laser or signal. The CAu-Mpy-SAu-SMnO2 nanoprobe is designed for the ratiometric SERS sensing in living cells, which retains sensing performances even though the Raman mol. is protected inside the nanostructure. This SERS strategy makes the turn-on sensing achievable in living cells with the MnO2 shell as a signal switch and a Raman reference Addnl., it allows for accurate monitoring of the degradation of MnO2 carriers in living cells, even without fluorescent labels.
After consulting a lot of data, we found that this compound(4556-23-4)Formula: C5H5NS can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts