Month: April 2022

Recommanded Product: 2,4,5-Triphenylimidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,4,5-Triphenylimidazole, is researched, Molecular C21H16N2, CAS is 484-47-9, about Iron-Phosphonate Nanomaterial: As a Novel and Efficient Organic-Inorganic Hybrid Catalyst for Solvent-Free Synthesis of Tri-Substituted Imidazole Derivatives. Author is Arpanahi, Foozhan; Mombeni Goodajdar, Bijan.

In this study, organic-metal nanocatalyst was synthesized by reacting ferric(II) chloride with organic phosphonate ligand. The particle size was controlled with the help of the surfactant. Nanoparticle structure was analyzed using Fourier transform IR, thermogravimetric anal., vibrating sample magnetometer, SEM, dispersive X-ray, Brunauer-Emmett-Teller isotherm and X-ray diffraction spectra. Next, its catalytic activity was investigated in the synthesis of heterocyclic compounds (2,4,5-trisubstituted imidazoles derivatives). Under optimal conditions, the products were obtained with good efficiency and short time. Products identification were evaluated using phys. data, FT-IR, 1H and 13C NMR anal. The results show that the new method, namely the use of iron-phosphonate nanostructures, is effective for the synthesis of trisubstituted imidazole derivatives This method has many advantages such as short reaction time, high yield, solvent free conditions, recyclability of the catalyst, and easy workup.

After consulting a lot of data, we found that this compound(484-47-9)Recommanded Product: 2,4,5-Triphenylimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhu, Guixian; Cheng, Lin; Liu, Gannan; Zhu, Lianqing researched the compound: Pyridine-4-thiol( cas:4556-23-4 ).Quality Control of Pyridine-4-thiol.They published the article 《Synthesis of gold nanoparticle stabilized on silicon nanocrystal containing polymer microspheres as effective surface-enhanced Raman scattering (SERS) substrates》 about this compound( cas:4556-23-4 ) in Nanomaterials. Keywords: gold nanoparticle silicon nanocrystal polymer microsphere SERS substrate; 4-mercaptopyridine; SERS; gold nanoparticle; pH value; silicon nanocrystal containing polymer microspheres. We’ll tell you more about this compound (cas:4556-23-4).

Developing ideal surface-enhanced Raman scattering (SERS) substrates is significant in biol. detection. Compared with free non-aggregated noble metal nanoparticles, loading metal nanoparticles on a large matrix can achieve a higher SERS effect due to the existence of many “”hot spots””. A novel SERS substrate with intense “”hot spots”” was prepared through reducing gold ions with silicon nanocrystal containing polymer microspheres. The substrate exhibits high SERS sensitivity with an enhancement factor of 5.4×107. By applying 4-mercaptopyridine as a Raman reporter, the developed SERS substrate can realize measurement of pH values. The intensity ratio of 1574 to 1607 cm-1 of 4-mercaptopyridine showed excellent pH sensitivity, which increased as the surrounding pH increased. With good stability and reliability, the pH sensor is promising in the design of biol. detection devices.

After consulting a lot of data, we found that this compound(4556-23-4)Quality Control of Pyridine-4-thiol can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of C11H19NO4S. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (R)-3-(tert-Butoxycarbonyl)-5,5-dimethylthiazolidine-4-carboxylic acid, is researched, Molecular C11H19NO4S, CAS is 117918-23-7, about Attachment of basic amino group to plasmepsin inhibitors exhibiting potent antimalarial activity. Author is Kashimoto, Keisuke; Hidaka, Koushi; Uemura, Tsuyoshi; Miura, Takuya; Freire, Ernesto; Kimura, Tooru; Kiso, Yoshiaki.

Plasmepsin (Plm) is a target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. So, we attached substituents on a structure of the highly potent Plm inhibitor KNI-10006. Among the derivatives, amino-substituted compound such as KNI-10538 exhibited enhanced antimalarial activity maintaining potent Plm II inhibitory activity. These results suggest that auxiliary substituents of specific basic group contribute to deliver the inhibitors to the target Plm. We further synthesized the alkylamino derivatives

After consulting a lot of data, we found that this compound(117918-23-7)Synthetic Route of C11H19NO4S can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17524-05-9, is researched, Molecular C10H14MoO6, about Synthesis and characterization of homobimetallic molybdenum(VI) complexes of a dihydrazone as efficient catalysts for the synthesis of hexahydroxyquinolines via multicomponent Hantzsch reaction, the main research direction is homobimetallic molybdenum complex catalyst aldehyde cyclohexanedione ethylacetoacetate Hantzsch; hexahydroxyquinolone preparation.Synthetic Route of C10H14MoO6.

Four homobimetallic molybdenum(VI) complexes [(MoO2)2L(D)2] (where D = methanol, dimethylsufoxide, imidazole and pyridine) derived from a multidentate hydrazone ligand, 1,4-bis(3-ethoxy-2-hydroxybenzaldehyde-carbohydrazonato)butane, H4L were synthesized by the reaction of the same with bis(acetylacetonato)dioxidomolybdenum(VI) in 1:2 ratio in presence of methanol, DMSO, imidazole and pyridine. The complexes are suggested to have six-coordinate octahedral stereochem. around molybdenum(VI) centers. The dihydrazone and the complexes synthesized are characterized by elemental anal., various spectroscopic techniques (like FT-IR, UV-Vis and 1H NMR) and TGA anal. The molybdenum complexes have been successfully utilized as catalysts for the synthesis of hexahydroxyquinolones via multicomponent Hantzsch reaction. Generally, decent conversions have been obtained.

After consulting a lot of data, we found that this compound(17524-05-9)Synthetic Route of C10H14MoO6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,9-Dimethyl-1,10-phenanthroline hemihydrate, is researched, Molecular C28H26N4O, CAS is 34302-69-7, about Structure of 2,9-dimethyl-1,10-phenanthroline hemihydrate.Computed Properties of C28H26N4O.

The title compound is tetragonal, space group I41/a, with a 14.258(3) and c = 22.286(4) Å; dc = 1.274(1) for Z = 16; final R = 0.041 for 1196 reflections. At. coordinates are given. Pairs of dimethylphenanthroline mols. related by a 2-fold axis are bridged by water mols. lying on the 2-fold axis and H bonded to one of the N atoms in each mol. The H bonds are long and far from linear; O-H 1.06(4), H…N 2.0(4), O…N 3.020(3) Å; O-H…N 154(3)°. This is presumably a consequence of the approx. parallel arrangement of the 2 phenanthroline mols. in the (phen)2.H2O complex, which are tilted 4.7(1)° with respect to each other; the atoms in 1 mol. are 3.50 to 3.81 Å from the plane of the other mol. On the other side of the phenanthroline is another phenanthroline related by a center of symmetry with the atoms of one mol. 3.41 to 3.45 Å from the plane of the other mol. The phenanthroline mol. has close to 2mm symmetry, but the individual C6 rings are tilted ∼1° with respect to each other.

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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Quality Control of Pyridine-4-thiol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Hydrogel microdomain encapsulation of stable functionalized silver nanoparticles for SERS pH and urea sensing.

Conceptual and com. examples of implantable sensors have been limited to a relatively small number of target analytes, with a strong focus on glucose monitoring. Recently, surface-enhanced Raman spectroscopy (SERS) pH sensors were demonstrated to track acid-producing enzymic reactions targeting specific analytes. We show here that SERS pH tracking in the basic regime is also possible, and can be used to monitor urea concentration To accomplish this, we developed a hydrogel consisting of polyelectrolyte multilayer microcapsules containing a SERS-sensitive pH reporter (4-mercapopyridine capped silver nanoparticles modified with bovine serum albumin). This pH sensing material exhibited a sensitive Raman scattering response to a wide range of pH from 6.5-9.7. By incorporating urease into the hydrogel matrix, the new sensor was capable of distinguishing urea concentrations of 0, 0.1, 1, and 10 mM. We also found that bovine serum albumin (BSA) prevented severe aggregation of the nanoparticle-based pH sensor, which improved sensing range and sensitivity. Furthermore, BSA safeguarded the pH sensor during the encapsulation procedure. Together, the combination of materials represents a novel approach to enabling optical sensing of reactions that generate pH changes in the basic range.

After consulting a lot of data, we found that this compound(4556-23-4)Quality Control of Pyridine-4-thiol can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4897-25-0, is researched, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2Journal, Huaxue Yanjiu Yu Yingyong called A new synthetic technique of 5-chloro-1-methyl-4-nitroimidazole, Author is Liu, Cong; Yan, Xiaofei; Ren, Yingge; Shen, Ning; Liu, Qianfeng, the main research direction is chloro methyl nitroimidazole preparation Azathioprine intermediate.Safety of 5-Chloro-1-methyl-4-nitroimidazole.

A method for the preparation of 5-chloro-1-methyl-4-nitroimidazole was developed with di-Et oxalate, aqueous methylamine formate, phosphorus pentachloride, mixed acid etc as starting materials. The synthesis of the target compound was achieved (64% yield) by a sequence involving an aminolysis reaction, condensation and nitration reaction. The process provided an energy-saving high yield synthetic method (green chem.) and the product thus obtained was confirmed by MS, NMR, FT-IR. The title compound is an intermediate for 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine [Azathioprine, Imuran, immunosuppressant].

After consulting a lot of data, we found that this compound(4897-25-0)Safety of 5-Chloro-1-methyl-4-nitroimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Enhanced charge-transfer induced by conduction band electrons in aluminum-doped zinc oxide/molecule/Ag sandwich structures observed by surface-enhanced Raman spectroscopy, published in 2022-03-15, which mentions a compound: 4556-23-4, mainly applied to aluminum doped zinc oxide silver sandwich structure charge transfer; Al-doped ZnO; Charge-transfer; Conduction band; SERS, Recommanded Product: 4556-23-4.

In the semiconductor/mol./metal system, enhancing the efficiency of the charge-transfer (CT) plays a pivotal role in improving the sensitivity of semiconductor-based surface-enhanced Raman scattering (SERS). In this work, use of SERS for detection of an enhanced CT in a chem.-etched Al-doped ZnO (AZO), 4-mercaptopyridine (MPy) mol., and Ag nanoparticles (NPs) (AZO/MPy/Ag) sandwich structure is reported. A series of CT routes are proposed in the energy level diagram of AZO/MPy/Ag assemblies under the excitation line at 633 nm. Very interestingly, for the first of its kind, a significant CT route from the conduction band (CB) of AZO to the LUMO (LUMO) of MPy mol. is detected. This route can remarkably improve the degree of CT in the AZO/MPy/Ag system by about 48% compared with that of the ZnO/MPy/Ag system. Furthermore, the uniquely enhanced CT route is also further confirmed by alternative probe mols. like p-aminothiophenol (PATP) and 4-mercaptobenzoic acid (MBA). The discovery of this extra CT route will inevitably play an irreplaceable role in SERS enhancement through its participating in the CT enhancement mechanism.

After consulting a lot of data, we found that this compound(4556-23-4)Recommanded Product: 4556-23-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, MedChemComm called Design, synthesis, and structure-activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists, Author is Adam, Julia M.; Cairns, Jim; Caulfield, Wilson; Cowley, Phillip; Cumming, Iain; Easson, Morag; Edwards, Darren; Ferguson, Morag; Goodwin, Richard; Jeremiah, Fiona; Kiyoi, Takao; Mistry, Ashvin; Moir, Elizabeth; Morphy, Richard; Tierney, Jason; York, Mark; Baker, James; Cottney, Jean E.; Houghton, Andrea K.; Westwood, Paul J.; Walker, Glenn, which mentions a compound: 128717-77-1, SMILESS is O=C(C1=CNC2=C1C=CC=C2OC)O, Molecular C10H9NO3, Synthetic Route of C10H9NO3.

A novel CB1 receptor agonist lead series was identified using a high-throughput screening approach. The initial screen afforded a single confirmed hit with poor water solubility Structural variations were explored with the aim of introducing water solubility and improving potency. This led to the discovery of Org 28611, a potent, water soluble CB1 receptor agonist, which was selected for clin. evaluation as a potential i.v. analgesic agent.

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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Stability-indicating assay for azathioprine and 6-mercaptopurine by reversed-phase high-performance liquid chromatography, published in 1979-12-30, which mentions a compound: 4897-25-0, Name is 5-Chloro-1-methyl-4-nitroimidazole, Molecular C4H4ClN3O2, Recommanded Product: 4897-25-0.

A rapid method based on reversed-phase high-performance liquid chromatog. is described for the separation and quantitation of azathioprine (I) [446-86-6], 6-mercaptopurine (II) [50-44-2] and their potential contaminants and degradants present in dosage forms. Procedures based on simple dissolution or extraction in 0.02 M NaOH give quant. precision of 1% relative standard deviation at the macro-level and 2% relative standard deviation for the microassay of analytes. The method is stability-indicating and was used for preliminary studies of the degradation of I in 0.9% NaCl injection, subjected to thermal or UV irradiation treatment. The content uniformity of dosage forms of I and II was measured. Only I injection as the freeze-dried Na salt [55774-33-9] contained detectable amounts of contaminants 1-methyl-4-nitro-5-chloroimidazole [4897-25-0] and hypoxanthine [68-94-0].

Although many compounds look similar to this compound(4897-25-0)Recommanded Product: 4897-25-0, numerous studies have shown that this compound(SMILES:C1=NC(=C(Cl)[N]1C)[N+]([O-])=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts