Month: April 2022

Formula: C5H5NS. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Can “”Hot Spots”” Be Stable Enough for Surface-Enhanced Raman Scattering?. Author is Zhu, Mei; Li, Moxia; Su, Mengke; Liu, Jianfang; Liu, Bingwu; Ge, Yongjie; Liu, Honglin; Hu, Jiawen.

Because of the random distribution and nonuniform enhancement of hot spots, surface-enhanced Raman scattering (SERS) usually shows poor spectral reproducibility, which greatly limits its practical applications, especially quant. SERS detection. Here, we report our finding that the instability of hot spots is also a key limiting factor for the poor spectral reproducibility of SERS. We show that hot spots show a stability threshold to the excitation power, duration, and wavelength. During SERS measurement, large spectral fluctuation is observed at or above a threshold power because the laser used reshapes (here, weld) the hot spots, causing a continuous decrease in SERS intensity. The threshold power also differs for different excitation wavelengths because of their different resonance extents with the plasmon of the hot spots. Finally, we show that a random SERS substrate can deliver much improved stable, reproducible SERS signals when lowering the excitation power below the threshold or deliberately removing the more unstable hot spots. These results offer a new understanding to the spectral reproducibility of SERS, greatly facilitating reliable SERS detection and the design of robust hot spots.

There are many compounds similar to this compound(4556-23-4)Formula: C5H5NS. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Simlandy, Amit Kumar; Lyu, Mao-Yun; Brown, M. Kevin researched the compound: P(t-Bu)3 Pd G3( cas:1445086-17-8 ).Recommanded Product: P(t-Bu)3 Pd G3.They published the article 《Catalytic Arylboration of Spirocyclic Cyclobutenes: Rapid Access to Highly Substituted Spiro[3.n]alkanes》 about this compound( cas:1445086-17-8 ) in ACS Catalysis. Keywords: spirocyclic cyclobutene preparation copper palladium nickel catalyzed arylboration; chiral spirocyclic borylated cyclobutane preparation crystal structure; mol structure chiral spirocyclic borylated cyclobutane. We’ll tell you more about this compound (cas:1445086-17-8).

A method to achieve the synthesis of highly substituted spirocyclic cyclobutanes is disclosed. The reaction involves the catalytic arylboration of cyclobutenes. Depending on the substitution pattern of the cyclobutene, either a Cu/Pd- or a Ni-catalyzed reaction was used. In the case of the Cu/Pd-catalyzed reactions, the identification of a Cu-complex for arylboration was crucial to observe high selectivity. The synthetic utility of the products is demonstrated, and the mechanistic details are discussed.

There are many compounds similar to this compound(1445086-17-8)Recommanded Product: P(t-Bu)3 Pd G3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bis(acetylacetonato)dioxomolybdenum(VI), is researched, Molecular C10H14MoO6, CAS is 17524-05-9, about MoS2-Stratified CdS-Cu2-xS Core-Shell Nanorods for Highly Efficient Photocatalytic Hydrogen Production, the main research direction is molybdenum cadmium copper sulfide nanorod photocatalyst hydrogen evolution reaction; water splitting molybdenum cadmium copper nanorod heterojunction photocatalyst; CuI@MoS2 catalytic and protective layers; femtosecond transient absorption; mapping surface charge distribution; photocatalytic water splitting; stratified CdS-Cu2−xS/MoS2.SDS of cas: 17524-05-9.

Heterojunction photocatalysts are widely adopted for efficient water splitting, but ion migration can seriously threaten the stability of heterojunctions, as with the well-known low stability of CdS-Cu2-xS due to intrinsic Cu+ ion migration. Here, Cu+ migration is utilized to design a stratified CdS-Cu2-xS/MoS2 photocatalyst, in which CuI@MoS2 (CuI-intercalated within the MoS2 basal plane) is created by Cu+ migration and intercalation to the adjacent MoS2 surface. The epitaxial vertical growth of the CuI@MoS2 nanosheets on the surface of one-dimensional core-shell CdS-Cu2-xS nanorods forms catalytic and protective layers to simultaneously enhance catalytic activity and stability. Charge transfer is verified by kinetics measurements with femtosecond time-resolved transient absorption spectroscopy and direct mapping of the surface charge distribution with a scanning ion conductance microscope. This design strategy demonstrates the potential of utilizing hybridized surface layers as effective catalytic and protective interfaces for photocatalytic hydrogen production

There are many compounds similar to this compound(17524-05-9)SDS of cas: 17524-05-9. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Jie; Dodd, Robert H. researched the compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate( cas:166329-43-7 ).Formula: C12H16BrNO2.They published the article 《Synthesis of 1,4-benzodiazepine-1-carbothioamides, bicyclic analogs of the TIBO-type anti-HIV agents》 about this compound( cas:166329-43-7 ) in Journal of Heterocyclic Chemistry. Keywords: TIBO analog preparation HIV virucide; benzodiazepinecarbothioamide TIBO analog preparation HIV. We’ll tell you more about this compound (cas:166329-43-7).

A series of N’-substituted 1,4-benzodiazepine-1-carbothioamides were prepared by reacting the precursor 1,4-benzodiazepine with the corresponding N-substituted isothiocyanates or with sodium thiocyanatotrifluoroacetic. Despite the structural resemblance of these mols. with the potent TIBO-type anti-HIV compound R82150, none of the compounds prepared displayed no anti-HIV activity in vitro.

There are many compounds similar to this compound(166329-43-7)Formula: C12H16BrNO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4897-25-0, is researched, SMILESS is C1=NC(=C(Cl)[N]1C)[N+]([O-])=O, Molecular C4H4ClN3O2Journal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Research Support, U.S. Gov’t, P.H.S., International Journal of Radiation Oncology, Biology, Physics called Radiosensitizing and cytotoxic properties of ortho-substituted 4- and 5-nitroimidazoles: role of NPSH reactivity, Author is Astor, Myles; Hall, Eric J.; Martin, John; Flynn, Marilyn; Biaglow, John; Parham, James C., the main research direction is nitroimidazole derivative radiosensitization cytotoxicity.Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole.

Chinese hamster (V79) cells were used to investigate the radiosensitizing efficiency and chem. reactivity with nonprotein sulfhydryl (NPSH) compounds such as GSH, for a series of ortho-substituted 4- and 5-nitroimidazoles. When added to cells 5 min prior to irradiation, MJL-1-191-VII (1-methyl-5-sulfonamide-4-nitroimidazole) (I) sensitizes hypoxic cells commensurate with its electron affinity, while not affecting the radiosensitivity of aerated cells. Both aerated and hypoxic cells show an increase in radiosensitivity after I incubation with the cells for a period of time at 37° prior to irradiation Under these conditions the radiosensitizing effectiveness towards hypoxic cells appears to be particularly anomalous, inasmuch as enhancement ratios similar to misonidazole can be obtained at concentrations of 50-100-fold lower. The isomer SK 21981 (1-methyl-4-sulfonamide-5-nitroimidazole) (II) does not behave in this anomalous way, but sensitizes to an extent predictable from its electron affinity. These compounds differ in the rate at which they react spontaneously and intracellularly with NPSH compounds such as GSH. Apparently, I sensitizes by 2 mechanisms, the 1st a function of its electron affinity and the 2nd a function of its rapid reaction with endogenous radioprotective and chemotherapeutic compounds in the cell.

There are many compounds similar to this compound(4897-25-0)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 484-47-9, is researched, Molecular C21H16N2, about Development of novel and green NiFe2O4/geopolymer nanocatalyst based on bentonite for synthesis of imidazole heterocycles by ultrasonic irradiations, the main research direction is nickel ferrite geopolymer nanocomposite preparation thermal stability; aryl aldehyde benzil ammonium acetate geopolymer nanocomposite multicomponent cyclocondensation; diphenyl arylimidazole preparation ultrasound green chem.Name: 2,4,5-Triphenylimidazole.

In this research, according to the fabrication of geopolymer based on bentonite as a substrate and embedment of NiFe2O4 nanoparticles in the construction of this polymer, the synthesis of a new magnetic nanocomposite (NiFe2O4/geopolymer) was investigated for the first time. In order to describe its chem. and morphol. features, different analyses such as Fourier transform IR spectroscopy, field-emission SEM and transmission electron microscopy images, Brunauer-Emmet-Teller adsorption-desorption isotherm, X-ray diffraction pattern, energy-dispersive X-ray anal., thermogravimetric anal., and vibrating-sample magnetometer anal. were used. The application of this novel nanocatalyst was studied for one-pot three-component condensation reaction of substituted imidazole derivatives by accelerated ultrasonic irradiations. Compared to the other conventional catalysts which were used for the synthesis of imidazole derivatives, the green synthesis method for fabrication of this heterogeneous and magnetic nanocatalyst, its high thermal stability, being eco-friendly, noticeable efficiency and easy reusability have become privileges to be superior.

There are many compounds similar to this compound(484-47-9)Name: 2,4,5-Triphenylimidazole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about Synthesis of sulfur-labeled 6-mercaptopurine and 6-[(1-methyl-4-nitroimidazol-5-yl)mercapto]purine.

6-Mercaptopurine-35S (I) was prepared in 83% yield by boiling 6-chloropurine with Ba35S in pyridine containing Ba(OH)2 and KHSO3. Boiling I in aqueous NaOH 4 hr with 1-methyl-4-nitro-5-chloroimidazole gave 80% II.

There are many compounds similar to this compound(4897-25-0)Application In Synthesis of 5-Chloro-1-methyl-4-nitroimidazole. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of C4H4ClN3O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Chloro-1-methyl-4-nitroimidazole, is researched, Molecular C4H4ClN3O2, CAS is 4897-25-0, about New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. Author is Saadeh, Haythem A.; Mosleh, Ibrahim M.; El-Abadelah, Mustafa M..

A number of 5-aryl-1-methyl-4-nitroimidazoles 5a-f have been synthesized in good yields by the Suzuki coupling reaction between 5-chloro-1-methyl-4-nitroimidazole and arylboronic acids, in the presence of dichlorobis(triphenylphosphine)palladium(II), K2CO3, and tetrabutylammonium bromide in water at 70-80 °C. On the basis of in vitro screening data, 5-(3-chlorophenyl)-1-methyl-4-nitro-1H-imidazole (I) exhibited potent lethal activity against Entamoeba histolytica and Giardia intestinalis with IC50 = 1.47 μM/mL, a value lower by a factor of two than that of the standard drug, metronidazole. The boosted activity of I was not accompanied by any increased cytotoxicity. The rest of the series also exhibited potent antiparasitic activity with IC50 values in the 1.72-4.43 μM/mL range. The cytotoxicity of 4-MeO and 4-Cl derivatives was increased compared to the precursor compound, metronidazole, although they remain non-cytotoxic at concentrations much higher than the antiparasitic concentration of the two derivatives

There are many compounds similar to this compound(4897-25-0)Electric Literature of C4H4ClN3O2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called The 4-Mercaptopyridine Modified Fiber Optic Plasmonic Sensor for Sub-nM Mercury (II) Detection, published in 2022-03-31, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Electric Literature of C5H5NS.

In this paper, we propose and demonstrate a high-performance mercury ion sensor with sub-nM detection limit, high selectivity, and strong practicability based on the small mol. of the 4-mercaptopyridine (4-MPY) modified tilted fiber Bragg grating surface plasmon resonance (TFBG-SPR) sensing platform. The TFBG-SPR sensor has a rich mode field distribution and a narrow bandwidth, which can detect the microscopic phys. and chem. reactions on the sensor surface with high sensitivity without being disturbed by the external temperature For the environmental compatibility and highly efficient capture of the toxic mercury ion, 4-MPY is modified on the sensor surface forming a stable (4-MPY)-Hg-(4-MPY) structure due to the specific combination between the nitrogen of the pyridine moiety and the Hg2+ via multidentate N-bonding. Moreover, gold nanoparticles (AuNPs) are connected to the sensor surface through the (4-MPY)-Hg-(4-MPY) structure, which could play an important role for signal amplification. Under the optimized conditions, the limit of detection of the sensor for mercury ions detection in the solution is as low as 1.643×10-10 M (0.1643nM), and the detection range is 1×10-9 M – 1×10-5 M. At the same time, the mercury ion spiked detection with tap water shows that the sensor has the good selectivity and reliability in actual water samples. We develop a valuable sensing technol. for on-time environmental Hg2+ detection and in-vivo point of care testing in clinic applications.

There are many compounds similar to this compound(4556-23-4)Electric Literature of C5H5NS. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khalifeh, Reza; Naseri, Vafa; Rajabzadeh, Maryam published an article about the compound: 2,4,5-Triphenylimidazole( cas:484-47-9,SMILESS:C1(C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N1 ).Application of 484-47-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:484-47-9) through the article.

The core-shell of Fe3O4@SiO2 modified by epichlorohydrin and 1-methylimidazole (Fe3O4@SiO2-EPIM), a new green recyclable nanocatalyst, was designed and prepared This nanocatalyst was characterized using Fourier-transform IR spectroscopy (FT-IR), field-emission SEM (FESEM), energy-dispersive X-ray spectroscopy (EDS), elemental mapping technique, transmission electron microscopy (TEM), X-ray diffraction (XRD) techniques, thermal gravimetric anal. (TGA), N2 adsorption-desorption by Brunauer-Emmet-Teller (BET) and vibrating sample magnetometer (VSM). The catalytic activity of Fe3O4@SiO2-EPIM was assessed for synthesis of 2-R-4,5-diphenylimidazoles (R = i-Bu, Ph, anthracen-9-yl, 2-PhCH:CH, furan-2-yl, etc.) via one-pot condensation reactions of benzil, aldehydes RCHO and ammonium acetate under the optimal reaction condition (PEG 200, 100°C, 0.02 g catalyst). This nanocatalyst displayed remarkable advantages, such as environmental friendliness, shorter reaction time, excellent yields, reusability of the catalyst and simple workup procedure.

There are many compounds similar to this compound(484-47-9)Application of 484-47-9. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts