Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. COA of Formula: C9H6BrNO.
Dhanavath, Ramulu;Dharavath, Ravinder;Kothula, Devender;Bitla, Sampath;Yaku, Gugulothu;Birdaraju, Saritha;Puchakayala, Muralidhar Reddy;Atcha, Krishnam Raju research published 《 Synthesis and biological evaluation of novel 2-arylquinoline-3-fused thiazolo [2,3-c]1,2, 4-triazole heterocycles as potential antiproliferative and antimicrobial agents》, the research content is summarized as follows. A series of novel 2-arylquinoline-3-fused thiazolo[2,3-c]1,2,4-triazole heterocycles I [R = H, Me; R1 = H, Cl, OMe; R2 = H, Me; R3 = H, OMe; R4 = H, Cl, OMe, CN] were efficiently synthesized using simple conventional methods in good yields. The structure of newly synthesized mols. was characterized on the basis of their IR, 1H NMR, 13C NMR and mass spectral data. Among compounds I, compounds I [R = R2 = R3 = H ; R1 = R4 = Cl], I [R = R2 = R3 = H, Me; R1 = R4 = OMe], I [R = R1 = R2 = R3 = H; R4 = Cl], I [R = R1 = R2 = R3 = H; R4 = OMe] exhibited highly significant antiproliferative activity against two cancer cell lines C6 (nerve cells) and MCF-7 (human breast adenocarcinoma cells) when compared with standard reference Doxorubicin. In vitro antimicrobial activities of target compounds compounds I [R = R2 = R3 = H ; R1 = R4 = Cl], I [R = R2 = R3 = H, Me; R1 = R4 = OMe], I [R = R1 = R2 = R3 = H; R4 = Cl], I [R = R1 = R2 = R3 = H; R4 = OMe], I [R = R2 = R3 = H ; R1 = OMe, R4 = Cl] were effectuated on Gram-pos. Staphylococcus aurus (ATCC 25923), Bacillus subtilis (ATCC 6633) and Gram-neg. strains Klebsiella Pneumonia (ATCC 31488) and Escherichia coli (ATCC 25966) strains and found to exhibit promising activity against standard Ciprofloxacin drug. Further, when in vitro antifungal activity was conducted on Aspergillus flavus and Aspergillus niger strains compounds I [R = R2 = R3 = H ; R1 = R4 = Cl], I [R = R2 = R3 = H, Me; R1 = R4 = OMe], I [R = R1 = R2 = R3 = H; R4 = Cl], I [R = R1 = R2 = R3 = H; R4 = OMe] were exhibited potent activity when compared with standard Fluconazole drug moiety.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., COA of Formula: C9H6BrNO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts