Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Quality Control of 20099-89-2.
Dharavath, Ravinder;Sarasija, M.;Ram Reddy, M.;Naga Prathima, K.;Nagarju, N.;Ramakrishna, K.;Ashok, D.;Daravath, Sreenu research published 《 Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones》, the research content is summarized as follows. A series of (3-methyl-7H-furo[2,3-]chromen-2-yl)(aryl)methanones I (R = 4-F, 4-Cl, 4-CN, etc.) were quickly prepared through easily accessible, short-span progress microwave irradiation and conventional heating methods. Further, the in vitro antiproliferative activities were tested against MCF-7 (human breast adenocarcinoma cells) and C-6 (nerve cells) using the MTT assay. The compounds I (R = 4-F) and I (R = 4-CN) a showed better antiproliferative activity than Cisplatin. Addnl., in vitro antibacterial and antifungal activities were carried out against different bacterial and fungal strains. Compounds I (R = 4-F), I (R = 4-Cl), and I (R = 4-CN) showed a substantial inhibition effect than Ciprofloxacin and Fluconazole standard drugs resp., UV-Visible and fluorescence measurements were conducted to assess the interaction of the compounds with CT-DNA compounds I (R = 4-Cl), I (R = 4-Br) and I (R = 4-CN) showed a stronger DNA binding affinity.
Quality Control of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts