Month: September 2022

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Related Products of 105-34-0.

Dutta, Arup;Goswami, Munmee;Rabha, Jintu;Das, Sukanya;Jha, Dhruva K.;Nongkhlaw, Rishanlang research published 《 Fe₃O₄@RB@LDH: Efficient and Recyclable Photocatalyst Visible-Light Mediated Synthesis of Pyran and Pyrrolidinone Derivatives and Their Anti-Microbial Activities》, the research content is summarized as follows. Selective and high yielding synthesis of pyrans, e.g., I and pyrrolidinone derivatives II [R = H, Cl, Me, OMe; R¹ = H, 3-Cl, 4-OH, etc.; R² = Me, Et] through a magnetic layered double hydroxide (LDH) visible light photocatalyst (VLPC)-promoted reaction is reported. The catalyst was prepared and characterized by various anal. techniques. Since it is magnetic the prepared catalyst could be easily separated from the reaction mixture by using an external magnet. The advantages of this synthetic protocol are good to excellent yields, short reaction times, easy catalyst recovery and recyclability. Also, in vitro antibacterial screening of pyrrolidinone derivative II was studied against gram-pos. Bacillus cereus (B. cereus), gram-neg. bacteria Escherichia coli (E. coli) and S. aureus. Compound II [R = H, R¹ = 3-Cl, R² = Me] exhibited the maximum activity against all the bacteria tested in the experiment

Related Products of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. SDS of cas: 3032-92-6.

Duan, Yongjie;Liang, Kun;Yin, Hongquan;Chen, Fu-Xue research published 《 Dithiocyanation of Alkynes with N-Thiocyanato-dibenzenesulfonimide and Ammonium Thiocyanate》, the research content is summarized as follows. An efficient dithiocyanation of alkynes with N-thiocyanato-dibenzenesulfonimide (NTSI) as the SCN+ cation and ammonium thiocyanate as the SCN- anion sources to form 1-(1,2-Dithiocyanato-2-(aryl)vinyl)-benzenes I [R¹ = Me, H, F, etc.; R² = t-Bu, 4-MeC₆H₄, 3-MeOC₆H₄, etc.] was developed. Highly active electrophilic reagent NTSI could react with various types of alkynes to build C(sp²)-SCN bond to provide a variety of dithiocyanato olefin compounds under simple and mild conditions. Trace amount of water was beneficial to the dissociation of ammonium thiocyanate, which makes the SCN- anion easier to participate in the reaction. The protocol owned a broad substrates scope including terminal and internal, alkyl and aryl alkynes, excellent functional group tolerance and good regioselectivity.

SDS of cas: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Formula: C8F4N2.

Dong, Hao;Zhu, Zhiyang;Li, Kaihua;Li, Qixuan;Ji, Wenhui;He, Benqiao;Li, Jianxin;Ma, Xiaohua research published 《 Significantly improved gas separation properties of sulfonated PIM-1 by direct sulfonation using SO₃ solution》, the research content is summarized as follows. One of the biggest challenges in membrane-based gas separation application is how to obtain highly efficient membranes with both high permeability and selectivity. To achieve this target, we reported a novel simple method to modify polymer of intrinsic microporosity (PIM-1) membranes by direct sulfonation using sulfur trioxide (SO₃)/dichloromethane solution to get a series of sulfonated PIM-1 (SPIM-1) membranes. The SO₃H group was bonded to the main chain of the SPIM-1 and distributed homogeneously in the entire membrane that was confirmed by FTIR, XPS and SEM/EDS mapping. As the sulfonation time increased from 2 to 6 min, the concentration of sulfonic acid (SO₃H) group in the repeat unit increased from 12.3% to 30.1%. The introduction of SO₃H groups resulted in a decreased surface area and denser polymer chain packing. The resulting SPIM-1 membranes exhibited huge improved selectivity with separation performance much better than the pristine PIM-1. In which, the 6 min sulfonated PIM-1 membrane (SPIM-1-6) showed excellent gas separation properties with its performance approaches or even exceeds the latest trade-off curves for O₂/N₂, CO₂/N₂, H₂/N_2, and CO₂/CH₄. This is due to the SO₃H group induced a compact packing of polymer main chain that remarkably enhanced the diffusion selectivity. The 60 days aged SPIM-1-6 demonstrated even higher gas pair selectivity, and the H₂/N₂ and O₂/N₂ selectivity reached as much as 125 and 8.43 coupled with H₂ and O₂ permeability of 1077 and 73.4 Barrer, resp. Addnl., the SPIM-1-6 also showed excellent mixed-gas separation properties, with CO₂/CH₄ mixed-gas selectivity over 40 coupled with CO₂ permeability of 296 Barrer even at the upstream pressure of 20 bar. These results suggested the great potential for this mild sulfonation method and sulfonated PIM-1 membranes in advanced membrane-based gas separation applications.

Formula: C8F4N2, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. HPLC of Formula: 105-34-0.

Divar, Masoumeh;Zomorodian, Kamiar;Sabet, Razieh;Moeini, Maryam;Khabnadideh, Soghra research published 《 An Efficient Method for Synthesis of Some Novel Spirooxindole-4H-Pyran Derivatives》, the research content is summarized as follows. In this study, an easy and efficient access to spirooxindoles I (R = Et, cyclopentyl, (3-bromophenyl)methyl, etc.; R¹ = CN, C(O)OCH₃, C(O)OCH₂CH₃) by multicomponent reaction of N-alkylated isatin derivatives II, an activated methylene R¹CH₂CN and 4-hydroxycoumarin to get such compounds powerfully and suitably was proposed. The reaction conditions were also optimized in the point of different kinds of catalysts, temperature, and solvents.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., HPLC of Formula: 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. Category: nitriles-buliding-blocks.

Ding, Sha;Fike, Katherine R.;Klemba, Michael;Carlier, Paul R. research published 《 In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs》, the research content is summarized as follows. Antimalarial candidates possessing novel mechanisms of action are needed to control drug resistant Plasmodium falciparum. We were drawn to Malaria Box compound 1 (MMV665831) by virtue of its excellent in vitro potency, and twelve analogs were prepared to probe its structure-activity relationship. Modulation of the di-Et amino group was fruitful, producing compound 25, which was twice as potent as 1 against cultured parasites. Efforts were made to modify the phenolic Mannich base functionality of 1, to prevent formation of a reactive quinone methide. Homologated analog 28 had reduced potency relative to 1, but still inhibited growth with EC₅₀ ≤ 200 nM. Thus, the antimalarial activity of 1 does not derive from quinone methide formation. Chem. stability studies on di-Me analog 2 showed remarkable hydrolytic stability of both the phenolic Mannich base and Et ester moieties, and 1 was evaluated for in vivo efficacy in P. berghei-infected mice (40 mg/kg, oral). Unfortunately, no reduction in parasitemia was seen relative to control. These results are discussed in the context of measured plasma and hepatocyte stabilities, with reference to structurally-related, orally-efficacious antimalarials.

Category: nitriles-buliding-blocks, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Computed Properties of 3032-92-6.

Ding, Ding;Xu, Liang;Wei, Yu research published 《 The Synthesis of α-Keto Acetals from Terminal Alkynes and Alcohols via Synergistic Interaction of Organoselenium Catalysis and Electrochemical Oxidation》, the research content is summarized as follows. Herein, an unprecedented electrochem. approach for the synthesis of α-keto acetals R¹C(O)CH(OR)₂ [R¹ = C₆H₅, 3-MeC₆H₄, 3,5-di-FC₆H₃, etc.; R² = Me, Et, n-Pr] was established, from readily available terminal alkynes and alcs. By merging the electrochem. and organoselenium-catalyzed processes, the desired products were obtained at room temperature in the absence of basic or metallic additives, with carbonyl and acetal motifs incorporated simultaneously across the triple bonds in a single operation.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Computed Properties of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Name: 4-(2-Bromoacetyl)benzonitrile.

Diaconu, Dumitrela;Amariucai-Mantu, Dorina;Mangalagiu, Violeta;Antoci, Vasilichia;Zbancioc, Gheorghita;Mangalagiu, Ionel I. research published 《 Ultrasound assisted synthesis of hybrid quinoline-imidazole derivatives: a green synthetic approach》, the research content is summarized as follows. A green, straightforward and efficient study for obtaining hybrid quinoline-imidazole derivatives under ultrasound (US) irradiation as well as under conventional thermal heating (TH) was presented. The reaction pathway involved only two steps: the N-alkylation of imidazole ring and a Huisgen [3 + 2] dipolar cycloaddition reaction of ylides to di-Me acetylenedicarboxylate. For both types of reactions, a green workup procedure under US irradiation was presented. Under US irradiation, the N-alkylation of nitrogen atoms from the imidazole nucleus had outstanding benefits in terms of reaction time, energy consumption and yields and thereby could be considered an environmentally friendly method. Forty new hybrid quinoline-imidazole compounds were synthesized: 18 salts such as I [R = H, CN, Br, etc.], 8 dihydro-benzopyrrolo imidazolo quinoline II, 9 benzopyrrolo-imidazolo quinoline III and 5 dihydro-pyrroloquinoxaline quinoline cycloadducts IV.

Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Quality Control of 20099-89-2.

Dharavath, Ravinder;Sarasija, M.;Ram Reddy, M.;Naga Prathima, K.;Nagarju, N.;Ramakrishna, K.;Ashok, D.;Daravath, Sreenu research published 《 Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones》, the research content is summarized as follows. A series of (3-methyl-7H-furo[2,3-]chromen-2-yl)(aryl)methanones I (R = 4-F, 4-Cl, 4-CN, etc.) were quickly prepared through easily accessible, short-span progress microwave irradiation and conventional heating methods. Further, the in vitro antiproliferative activities were tested against MCF-7 (human breast adenocarcinoma cells) and C-6 (nerve cells) using the MTT assay. The compounds I (R = 4-F) and I (R = 4-CN) a showed better antiproliferative activity than Cisplatin. Addnl., in vitro antibacterial and antifungal activities were carried out against different bacterial and fungal strains. Compounds I (R = 4-F), I (R = 4-Cl), and I (R = 4-CN) showed a substantial inhibition effect than Ciprofloxacin and Fluconazole standard drugs resp., UV-Visible and fluorescence measurements were conducted to assess the interaction of the compounds with CT-DNA compounds I (R = 4-Cl), I (R = 4-Br) and I (R = 4-CN) showed a stronger DNA binding affinity.

Quality Control of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. COA of Formula: C9H6BrNO.

Dhanavath, Ramulu;Dharavath, Ravinder;Kothula, Devender;Bitla, Sampath;Yaku, Gugulothu;Birdaraju, Saritha;Puchakayala, Muralidhar Reddy;Atcha, Krishnam Raju research published 《 Synthesis and biological evaluation of novel 2-arylquinoline-3-fused thiazolo [2,3-c]1,2, 4-triazole heterocycles as potential antiproliferative and antimicrobial agents》, the research content is summarized as follows. A series of novel 2-arylquinoline-3-fused thiazolo[2,3-c]1,2,4-triazole heterocycles I [R = H, Me; R¹ = H, Cl, OMe; R² = H, Me; R³ = H, OMe; R⁴ = H, Cl, OMe, CN] were efficiently synthesized using simple conventional methods in good yields. The structure of newly synthesized mols. was characterized on the basis of their IR, ¹H NMR, ¹³C NMR and mass spectral data. Among compounds I, compounds I [R = R² = R³ = H ; R¹ = R⁴ = Cl], I [R = R² = R³ = H, Me; R¹ = R⁴ = OMe], I [R = R¹ = R² = R³ = H; R⁴ = Cl], I [R = R¹ = R² = R³ = H; R⁴ = OMe] exhibited highly significant antiproliferative activity against two cancer cell lines C6 (nerve cells) and MCF-7 (human breast adenocarcinoma cells) when compared with standard reference Doxorubicin. In vitro antimicrobial activities of target compounds compounds I [R = R² = R³ = H ; R¹ = R⁴ = Cl], I [R = R² = R³ = H, Me; R¹ = R⁴ = OMe], I [R = R¹ = R² = R³ = H; R⁴ = Cl], I [R = R¹ = R² = R³ = H; R⁴ = OMe], I [R = R² = R³ = H ; R¹ = OMe, R⁴ = Cl] were effectuated on Gram-pos. Staphylococcus aurus (ATCC 25923), Bacillus subtilis (ATCC 6633) and Gram-neg. strains Klebsiella Pneumonia (ATCC 31488) and Escherichia coli (ATCC 25966) strains and found to exhibit promising activity against standard Ciprofloxacin drug. Further, when in vitro antifungal activity was conducted on Aspergillus flavus and Aspergillus niger strains compounds I [R = R² = R³ = H ; R¹ = R⁴ = Cl], I [R = R² = R³ = H, Me; R¹ = R⁴ = OMe], I [R = R¹ = R² = R³ = H; R⁴ = Cl], I [R = R¹ = R² = R³ = H; R⁴ = OMe] were exhibited potent activity when compared with standard Fluconazole drug moiety.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., COA of Formula: C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Quality Control of 20099-89-2.

De-Zordo Banliat, Arnaud;Grollier, Kevin;Damond, Aurelie;Billard, Thierry;Dagousset, Guillaume;Magnier, Emmanuel;Pegot, Bruce research published 《 Solvent-free nucleophilic selenocyanation with [bmim][SeCN]. Direct access to perfluoroalkylselenide compounds》, the research content is summarized as follows. Available online-1-n-butyl-3-methylimidazolium selenocyanate ([bmim][SeCN]) proved to be a very efficient reagent for selenocyanation of alkyl halides RBr [R = n-decyl, 6-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)hexyl, 9H-fluoren-9-yl, etc.]. As part of an eco-friendly process, no organic solvents were used during the transformation and reaction times were reduced by using microwave as a heating source. The ionic liquid was carefully recycled in two different ways. Selenocyanate compounds RSeCN were successfully transformed into (trifluoromethyl or polyfluoro)selenides RSeR¹ (R¹ = CF₃, CF₂Br, C₂F₅) in a one-pot two step procedure.

Quality Control of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts