Month: September 2022

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: Tetrafluoroterephthalonitrile.

Devarajan, Anirudh;Asuquo, Edidiong D.;Ahmad, Mohd Zamidi;Foster, Andrew B.;Budd, Peter M. research published 《 Influence of Polymer Topology on Gas Separation Membrane Performance of the Polymer of Intrinsic Microporosity PIM-Py》, the research content is summarized as follows. The polymer synthesis of 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile-3,3,3′,3′-tetramethyl-1,1′-spirobisindane-5,5′,6,6′-tetrol copolymer, termed PIM-Py, was investigated under different solvent (DMF and dimethylacetamide/dichlorobenzene) and temperature (65-160°C) conditions to produce a range of topol. different polymer samples. Characterization of the polymers, particularly with proton NMR spectroscopy and multiple detector SEC anal., indicated that, like PIM-1, the polymerizations proceeded with a degree of polymer chain branching. This is attributed to the occurrence of monosubstitution reactions, instead of disubstitution, which eventually leads to a significant proportion of colloidal network formation. However, all polymer samples remained soluble/dispersible in chloroform at the concentration required to cast self-standing films. This work reports the first examination of PIM-Py as a membrane for gas separation applications. The most structurally diverse PIM-Py samples produced films that exhibited selectivity/permeability balances in single gas permeation studies above the 2008 Robeson upper bound for the CO₂/N₂ gas pair. Indeed, a film cast from the highest colloidal network content sample surpassed the recently introduced 2019 CO₂/N₂ upper bound. After 143 days of aging, a 40μm self-standing membrane still exhibited a single gas CO₂ permeability of 4480 barrer and an ideal CO₂/N₂ selectivity of 45. The polymers produced in lower temperature reactions in DMF exhibited gas separation performances very similar to a structurally regular “normal” PIM-1 polymer, sitting on or around the 2008 Robeson upper bound line. Single gas permeation measurements to determine CO₂/CH₄ selectivity showed similar trends across the range of polymer samples, without generally reaching high selectivities as for the CO₂/N₂ pair. Mixed gas CO₂/CH₄ permeation measurements with aging were also completed for PIM-Py membranes, which indicated similar gas separation performance to a structurally regular PIM-1 polymer. This study would suggest that, like PIM-1, gas separation performance of PIM-Py is greatly influenced by the topol. balance toward branched and network material within the polymer sample.

Recommanded Product: Tetrafluoroterephthalonitrile, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , 1835-49-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C9H6BrNO.

Deshpande, Anant;Dhawale, Shashikant;Bari, Sanjaykumar;Bonde, Chandrakant research published 《 Design, synthesis and biological investigation of some novel quinazolin-4(3H)-one tethered 1,3,4-thiadiazole-thiol motifs as direct enoyl acyl carrier protein reductase inhibitors》, the research content is summarized as follows. In this study two noteworthy pharmacophores quinazolin-4(3H)-one and 1,3,4-thiadiazole through methylene bridge were utilized to design, synthesize and characterize some novel 2-Me quinazolin-4(3H)-one and 6-chloro-2-Me quinazolin-4(3H)-one tethered S-substituted-1,3,4-thiadiazole-thiol structural analogs resp. as direct Mycobacterium Tuberculosis (MTB) enoyl acyl carrier protein reductase (InhA) inhibitors. Structural analogs of quinazolin-4(3H)-one tethered 1,3,4-thiadiazole-thiol I [R = H, Cl; R¹ = 4-Me, 4-F, 3-NO₂, etc.] through methylene bridge by functional group modifications in core scaffold followed by computational studies to select promising compds was designed. The mol. docking of designed compunds was carried out using schrodinger Glide XP into the active site of MTB InhA with protein data bank code (PDB ID: 2H7M). The interactions were evaluated based on the glide G score compared with reference standard isoniazid. Ten new compounds I were synthesized, characterized and screened for their in-vitro antitubercular activity by Microplate Almar Blue Assay (MABA) method followed by cytotoxicity evaluation of compounds I [R = H ; R¹ = 4-F, 4-OMe] using Vero cell line. All the designed compounds of series I had drug-like characteristics and were non-toxic to normal cells. In the mol. docking studies, compounds I [R = H, Cl; R¹ = 4-F, 4-OMe] demonstrated strong binding affinity in the active region of MTB InhA protein and retained necessary amino acid interaction, similar to co-crystal 2H7M. Synthesized compounds I were found to have good antitubercular activity. Out of the series the compounds I [R = H ; R¹ = 4-F, 4-OMe] were found to possess excellent antitubercular activity equipotent to reference standard streptomycin with min. inhibitory concentration (MIC) value of 6.25μg/mL. The cytotoxic potential of compounds I [R = H ; R¹ = 4-F, 4-OMe] showed remarkable selectivity index against Vero cell line. The findings of this study highlighted the importance of tethering two pharmacophoric motifs in one compound to develop novel antitubercular agents that can be exploited as promising leads as direct InhA inhibitors.

Product Details of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Demirtas, Ilknur;Ertas, Erdal;Topal, Sebahat;Ozturk, Turan research published 《 Electropolymers of 4-(thieno[3,2-b]thiophen-3-yl)benzonitrile extended with thiophene, 3-hexylthiophene and EDOT moieties; their electrochromic applications》, the research content is summarized as follows. Three new π-conjugated 4-(thieno[3,2-b]thiophen-3-yl)benzonitrile based monomers having thiophene, 3-hexylthiophene and EDOT at the peripherals were synthesized. Their electropolymerization produced the corresponding electroactive polymers, P1, P2, and P3, which exhibited electrochromic properties with color developments from red to blue, orange-yellow to pale-blue, and purple to pale-gray, resp. Functional design of the monomers with electron deficient benzonitrile at β-position of thieno[3,2-b]thiophene (TT) and electron-rich thienyl groups at the peripherals influenced the HOMO and LUMO levels and, thereby, reduced the band gap of the conjugated polymers. Considering the band gaps of electropolymerized TT based polymers in the literature, the polymer P3, obtained through electropolymerization, had a comparable band gap of 1.73 eV. Electrochromic devices (ECD) of the new polymers displayed different optical contrasts (ΔT%) of 20% at 507 nm, 25% at 443 nm, and 34% at 579 nm for P1/PProDOP, P2/PProDOP, and P3/PProDOP, resp. Furthermore, they had modest switch times of 1.2-1.7 s for bleaching and 0.9-1.7 s for coloring. The polymers, P3/PProDOP, bearing EDOT moieties, had a reasonable coloration efficiency (CE) of 240 cm²/C at 579 nm, excellent permanent memory effect, and high stability of color switch, retaining 88% of its electroactivity after 500 cycles, switching at the applied voltages of -0.2 and + 1.1 V.

Category: nitriles-buliding-blocks, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Demirelli, Kadir;Abubakar, Abdullahi Musa;Tuncer, Hulya;Salih, Bekir research published 《 Preparation, characterization and electrical behaviors of greenish single-chain polymeric molecule-via intramolecular ball type cobalt phthalocyanines/ graphite oxide composites》, the research content is summarized as follows. The greenish single-chain polymeric mol.-ball type CoPc (SCPM-ball type CoPc) was prepared via the intramol. formation of cobalt phthalocyanine from polystyrene-co-poly[4,4′-((((4-vinylbenzyl)azanediyl)bis(ethane-2,1diyl))bis(oxy))diphthalonitrile] [P(PNDEAMSt12%-co-St)] (linear copolymer precursor) under diluted conditions at 150°C. The structure of SCPM-ball type CoPc was confirmed by FT-IR, MALDI-TOF-MS, UV and SEM. The conversion dependence of the exptl. activation energy was readily determined by an isoconversional method. So, the Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) showed that the linear copolymer precursor’s activation energies were as average 128.7 kJ/mol and 124.0 kJ/mol and those of SCPM-ball type CoPc were average 161.9 kJ/mol and 153.8 kJ/mol, resp. Conductivity mechanism of composites was suggested as Correlated Barrier Hoping (CBH). The linear copolymer precursor/graphite oxide (GO) composite has a significant performance for dielec. constant of 696.4 at 130°C, but it was with a comparatively greater dielec. loss. Those of SCPM-ball type CoPc/14wt% GO increased virtually the same relative ratio.

Category: nitriles-buliding-blocks, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Reference of 105-34-0.

de Abrantes, Paloma Gomes;Costa, Israel Ferreira;Falcao, Nathalia Kellyne da Silva Marinho;de Oliveira Ferreira, Joao Marcos Gomes;Junior, Claudio Gabriel Lima;Teotonio, Ercules Epaminondas de Sousa;Vale, Juliana Alves research published 《 The Efficient Knoevenagel Condensation Promoted by Bifunctional Heterogenized Catalyst Based Chitosan-EDTA at Room Temperature》, the research content is summarized as follows. An efficient heterogeneous catalyst-based low mol. weight chitosan (LWC) modified with EDTA groups were prepared and applied as a bifunctional heterogenized catalyst in the Knoevenagel Condensation reaction, promoting fast reactions between malononitrile and aldehydes or isatins at room temperature Chitosan-EDTA (LWC-EDTA) catalysts were characterized by Fourier transform IR spectroscopy (FT-IR), thermogravimetric anal. (TGA/DTA), powder X-ray diffraction (XRD). UV-Vis absorption spectrophotometry showed that the functionalization of chitosan with EDTA for 72 h promotes the most significant modification of the matrix surface compared to the others applied, reflecting shorter reaction times. The reactions using the LWC-EDTA-72 catalyst present excellent isolated yields (78-98%) in short reaction times (0.50-120 min) for differents Knoevenagel compounds Additionaly, the catalyst was easily recovered and reused up to six times without significant losses of its catalytic activity.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Reference of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Product Details of C9H6BrNO.

Das, Sumit;Singh, Bhagat;Fadikar, Pulak;Barman, Piyali Deb;Paira, Rupankar research published 《 Application of recyclable base-washed graphene oxide for one-pot conversion of 2-aminopyridines into 3-iodo-imidazo[1,2-a]pyridines at room temperature in water》, the research content is summarized as follows. A green synthetic protocol for cyclization of 2-aminopyridines I (R = H, 3-Me, 4-Me, 4-Cl, 4-Br, 5-Cl) with 2-bromoacetophenones R¹C(O)CH₂Br (R¹ = 4-bromophenyl, 3-tert-butylphenyl, naphthalen-2-yl, etc.) to prepare imidazo[1,2-a]pyridines, followed by their successive iodination in one-pot manner to give II (R² = H, 7-Me, 8-Me, 6-Cl, 7-Cl, 7-Br), employing base-washed graphene oxide as the catalyst, in water has been described. The current approach has offered to carry out the reaction in water medium at room temperature and the base-washed graphene oxide catalyst has provided excellent product yield (upto 81%) and can also be recycled effortlessly upto 5 catalytic cycles, through a simple base-wash protocol. The catalyst is an inexpensive, environmentally benign, green, and heterogeneous platform and has been characterized by IR, Raman, SEM and TEM studies.

Product Details of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Name: 4-Ethynylbenzonitrile.

Cui, Jian-Fang;Yu, Qiong;O, Wa-Yi;Huang, Li-Wu;Yang, Bin;Wong, Man-Kin research published 《 Synthesis of 1H-isoindoliums by electrophile-mediated cascade cyclization/iodination of propargylamine-based 1,6-diynes》, the research content is summarized as follows. A highly regio- and chemoselective synthesis of 1H-isoindoliums I [R¹ = Ph, 3-MeC₆H₄, 3-thienyl, etc.; R² = CH₂, CH(Me), O; R³ = H, 6-Me, 5-Cl, 6-Cl, 6-MeO, 6-CF₃] through a facile and novel cascade cyclization reaction of propargylamine-based 1,6-diynes under mild conditions had been developed. Different functional groups were compatible under the optimized reaction conditions, giving the corresponding products in up to 94% yields. Upon treatment with a base, the alkyne moiety of 1H-isoindoliums could be further transformed to allenes II [R⁴ =CH₂, O; R⁵ = Ph, 4-FC₅H₄, 4-NCC₆H₄; R⁶ = H] in excellent yields.

Name: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Reference of 105-34-0.

Cottrez, Francoise;Leblanc, Virginie;Boitel, Elodie;Groux, Herve;Alepee, Nathalie research published 《 The EyeIRR-IS assay: Development and evaluation of an in vitro assay to measure the eye irritation sub-categorization of liquid chemicals》, the research content is summarized as follows. Several alternative methods have been developed and regulatory adopted by OECD as in vitro alternatives to the Draize eye irritation assay either to detect chems. not requiring classification (No Category) or inducing serious damage to the eye (Category 1) but none are sensitive enough to identify chems. inducing reversible eye effects (category 2) which are categorised by default. Therefore, the discriminatory power of a genomic approach applied to the SkinEthic Human Corneal Epithelium (HCE) model was investigated to allow subcategorization capacity according to UN GHS classification. An algorithm based on gene expression modulation on a training (62) and a test (31 liquids) chem. set, tested neat and at 30%was evaluated in an assay called EyeIRR-IS. Its accuracy prediction to distinguish Cat1/Cat2 from No Cat was 95% with a specificity of 89% and a sensitivity of 98%. For subcategorization into the 3 GHS classes the accuracy reached 84% with 94% Cat1, 67% Cat2 and 89% No Cat correctly predicted. No Cat.1 chems. were underestimated as neg. with a majority of misclassified Cat2 over predicted as Cat 1. In conclusion, the performance of the assay suggests its added value in a defined approach for liquids to replace the Draize assay.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Reference of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. SDS of cas: 1835-49-0.

Cosey, Whitney K.;Balkus, Kenneth J. Jr.;Ferraris, John P.;Musselman, Inga H. research published 《 Reduced Aging in Carbon Molecular Sieve Membranes Derived from PIM-1 and MOP-18》, the research content is summarized as follows. Carbon mol. sieve membranes (CMSMs) commonly lose permeability over time due to the collapse of micropores. This decline in permeability, due to the densification of the membrane, is known as phys. aging. CMSMs derived from polymers of intrinsic microporosity (PIM-1) are highly affected by phys. aging, with declines in permeability greater than 60% over time. The densification of CMSMs derived from this high-free-volume polymer precursor is thermodynamically driven by the collapse of large unconnected graphene domains to reach a more stable conformation (i.e., graphite). This study describes a novel strategy to mitigate phys. aging by pillaring the CMSM using copper nanoparticles. Highly soluble metal-organic polyhedra-18 (MOP-18) was introduced into PIM-1 with loadings up to 40 wt/wt to form a mixed-matrix membrane (MMM). Pyrolysis of the MMM at 550°C resulted in the in situ formation of copper metal nanoparticles that acted as pillars for the graphene sheets within the CMSM, preventing the collapse of the micropores, thus minimizing the aging of the CMSM. Single gas permeation measurements of CO₂ and CH₄ were made on the pristine polymer-derived CMSM and the copper-pillared CMSM at 35°C and 2 bar to confirm the membranes’ resistance to phys. aging. The CH₄ permeability for the PIM-1 CMSM decreased by ∼60%, from 64 to 27 Barrers, over a period of 7 days, while the copper-pillared PIM-1 CMSM remarkably showed essentially no decline in CH₄ permeability. This research demonstrates a general approach to reducing phys. aging in CMSMs.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , SDS of cas: 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 1835-49-0, formula is C8F4N2, Name is Tetrafluoroterephthalonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 1835-49-0.

Corrado, Tanner J.;Huang, Zihan;Huang, Dezhao;Wamble, Noah;Luo, Tengfei;Guo, Ruilan research published 《 Pentiptycene-based ladder polymers with configurational free volume for enhanced gas separation performance and physical aging resistance》, the research content is summarized as follows. Polymers of intrinsic microporosity (PIMs) have shown promise in pushing the limits of gas separation membranes, recently redefining upper bounds for a variety of gas pair separations However, many of these membranes still suffer from reductions in permeability over time, removing the primary advantage of this class of polymer. In this work, a series of pentiptycene-based PIMs incorporated into copolymers with PIM-1 are examined to identify fundamental structure-property relationships between the configuration of the pentiptycene backbone and its accompanying linear or branched substituent group. The incorporation of pentiptycene provides a route to instill a more permanent, configuration-based free volume, resistant to phys. aging via traditional collapse of conformation-based free volume PPIM-i.p.-C and PPIM-np-S, copolymers with C- and S-shape backbones and branched isopropoxy and linear n-propoxy substituent groups, resp., each exhibited initial separation performance enhancements relative to PIM-1. Addnl., aging-enhanced gas permeabilities were observed, a stark departure from the typical permeability losses pure PIM-1 experiences with aging. Mixed-gas separation data showed enhanced CO2/CH4 selectivity relative to the pure-gas permeation results, with only ∼20% decreases in selectivity when moving from a CO2 partial pressure of ∼2.4 to ∼7.1 atm (atm. pressure) when utilizing a mixed-gas CO2/CH4 feed stream. These results highlight the potential of pentiptycene’s intrinsic, configurational free volume for simultaneously delivering size-sieving above the 2008 upper bound, along with exceptional resistance to phys. aging that often plagues high free volume PIMs.

1835-49-0, Tetrafluoroterephthalonitrile can react with alkyl grignard reagents to form 4-alkyltetraflurorobenzonitriles. It acts as a four electron donor ligand. Tetrafluoroterephthalonitrile can be used to synthesize polymers of intrinsic microporosity. It has been used to study UV rearranged polymers of teh PIM-1 type membrane for the efficient separation of H2 and CO2.
Tetrafluoroterephthalonitrile reacts with alkyl Grignard reagents to form corresponding 4-alkyltetrafluorobenzonitriles. Tetrafluoroterephthalonitrile acts as a four-electron donor ligand and forms tungsten(II)η 2-nitrile complexes.
Tetrafluoroterephthalonitrile is a hydroxyl group-containing organic chemical compound . It has been used in analytical chemistry as a reagent for the determination of peptide binding constants and disulfide bonds. Tetrafluoroterephthalonitrile binds to nucleophilic sites on proteins, such as the pim-1 protein, and can be used to transport other molecules across cell membranes. In addition, it has been used to produce polymers for use in analytical chemistry. This chemical is also able to bind with magnetic particles under constant pressure conditions, which makes it useful for optical sensor applications. , Reference of 1835-49-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts