Faraggi, Tomer M.; Rouget-Virbel, Caroline; Rincon, Juan A.; Barberis, Mario; Mateos, Carlos; Garcia-Cerrada, Susana; Agejas, Javier; de Frutos, Oscar; MacMillan, David W. C. published their research in Organic Process Research & Development in 2021. The article was titled 《Synthesis of enantiopure unnatural amino acids by metallaphotoredox catalysis》.Category: nitriles-buliding-blocks The article contains the following contents:
We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogs of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technol. The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Category: nitriles-buliding-blocks)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Category: nitriles-buliding-blocks 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts