Graham, Mark A.; Noonan, Gary; Cherryman, Janette H.; Douglas, James J.; Gonzalez, Miguel; Jackson, Lucinda V.; Leslie, Kevin; Liu, Zhi-qing; McKinney, David; Munday, Rachel H.; Parsons, Chris D.; Whittaker, David T. E.; Zhang, En-xuan; Zhang, Jun-wang published an article on January 15 ,2021. The article was titled 《Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction》, and you may find the article in Organic Process Research & Development.Recommanded Product: 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile The information in the text is summarized as follows:
New route development activities toward ceralasertib (AZD6738) have resulted in the discovery of an efficient, acid additive-free, photoredox Minisci reaction. Mechanistic understanding resulting from LED-NMR reaction profiling, quantum yield measurements, and Stern-Volmer quenching studies have enabled optimization of the catalyst system, resulting in a significant enhancement in the rate of reaction. A large-scale continuous photoflow process has been developed, providing encouraging proof-of-concept data for the future application of this technol. in the clin. manufacture of ceralasertib. In the part of experimental materials, we found many familiar compounds, such as 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Recommanded Product: 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile)
2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Recommanded Product: 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts