In 2017,Ketels, Marthe; Ganiek, Maximilian A.; Weidmann, Niels; Knochel, Paul published 《Synthesis of Polyfunctional Diorganomagnesium and Diorganozinc Reagents through In Situ Trapping Halogen-Lithium Exchange of Highly Functionalized (Hetero)aryl Halides in Continuous Flow》.Angewandte Chemie, International Edition published the findings.Product Details of 105942-08-3 The information in the text is summarized as follows:
Using com. available flow reactors, di(hetero)arylmagnesium and di(hetero)arylzinc reagents containing normally incompatible functional groups such as azides, nitro groups, isothiocyanates, esters, and ketones were generated in situ by lithium-metal exchange reactions of aryl bromides or iodides such as 1-azido-4-iodobenzene with BuLi or PhLi and transmetalation with either MgCl2·LiCl or ZnCl2. Reaction of the di(hetero)arylmagnesium and di(hetero)arylzinc reagents with electrophiles such as allyl bromide, cyclopropanecarbonyl chloride, and cyclopropyl 4-fluorophenyl ketone mediated by CuCN·2 LiCl or palladium-catalyzed coupling reactions yielded (hetero)arene-containing products such as 4-N3C6H4CH2CH:CH2 in 62-85% yields. The preparation of 4-(4-bromobenzoyl)-2-fluorobenzonitrile was performed by this method on 10 mmol scale without further optimization. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts