In 2017,Angewandte Chemie, International Edition included an article by Toop, Hamish D.; Brusnahan, Jason S.; Morris, Jonathan C.. Related Products of 53005-44-0. The article was titled 《Concise Total Synthesis of Dioncophylline E through an ortho-Arylation Strategy》. The information in the text is summarized as follows:
The first total synthesis of the potent antimalarial 7,3′-linked naphthylisoquinoline alkaloid dioncophylline E (I) has been completed. The synthesis proceeds in 12 steps (longest linear sequence) and in 15 % overall yield. Key transformations include an ortho-arylation of a naphthol with an aryllead triacetate to construct the sterically hindered biaryl bond, and a three-step sequence to stereoselectively generate the trans-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline moiety. In the experiment, the researchers used 2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0Related Products of 53005-44-0)
2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Related Products of 53005-44-0 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts