Wang, Xing-Rong; Wang, Shuai; Li, Wen-Bo; Xu, Kai-Yan; Qiao, Xue-Peng; Jing, Xue-Li; Wang, Zi-Xiao; Yang, Chang-jiang; Chen, Shi-Wu published an article in 2021. The article was titled 《Design, synthesis and biological evaluation of novel 2-(4-(1H-indazol-6-yl)-1H-pyrazol-1-yl)acetamide derivatives as potent VEGFR-2 inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Product Details of 105942-08-3 The information in the text is summarized as follows:
Vascular endothelial growth factor-2 (VEGFR-2) plays a pivotal role in tumor angiogenesis. Herein, a library of novel 2-(4-(1H-indazol-6-yl)-1H-pyrazol-1-yl)acetamide derivatives were designed and synthesized as VEGFR-2 inhibitors based on scaffold hopping strategy. These compounds exhibited excellent inhibitory activity in both VEGFR-2 and tumor cell proliferation. Especially, compound I possessed potent VEGFR-2 inhibition with IC50 = 1.6 nM and anti-proliferation against HGC-27 tumor cells with IC50 = 0.36 +/- 0.11μM, as well as less toxicity against normal GES-1 cells with IC50 = 187.46 +/- 10.13μM. Moreover, I obviously inhibited colony formation, migration and invasion of HGC-27 cells by adjusting the expression of MMP-9 and E-cadherin, and induced HGC-27 cells apoptosis by increasing ROS production and regulates the expression of apoptotic proteins. Furthermore, I blocked the PI3K-Akt-mTOR signaling pathway in HGC-27 cells. In addition, anti-angiogenesis of I was proved by inhibition tube formation and the expression of p-VEGFR-2 in HUVEC cells. All the results demonstrated that I could be developed as a promising anticancer agent for gastric cancer therapy. After reading the article, we found that the author used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Product Details of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts