Zhang, Lei; Rogers, Bruce N.; Duplantier, Allen J.; McHardy, Stanley F.; Efremov, Ivan; Berke, Helen; Qian, Weimin; Zhang, Andy Q.; Maklad, Noha; Candler, John; Doran, Angela C.; Lazzaro, John T.; Ganong, Alan H. published the artcile< 3-(Imidazolylmethyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators>, Application In Synthesis of 6136-93-2, the main research area is imidazolylmethylazabicyclohexanol ether preparation metabotropic glutamate receptor modulator.
The synthesis and structure-activity relationship of a novel series of 3-(imidazolylmethyl)-3-azabicyclo[3.1.0]hexan-6-ylmethyl ethers, derived from a high throughput screening, are described. Subsequent optimization led to identification of potent, metabolically stable and orally available mGluR2 pos. allosteric modulators.
Bioorganic & Medicinal Chemistry Letters published new progress about Metabotropic glutamate receptor 2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Application In Synthesis of 6136-93-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts