Utimoto, Kiitiro; Wakabayashi, Yukio; Horiie, Takafumi; Inoue, Masaharu; Shishiyama, Yuho; Obayashi, Michio; Nozaki, Hitosi published the artcile< Cyanotrimethylsilane as a versatile reagent for introducing cyanide functionality>, Computed Properties of 6136-93-2, the main research area is cyanotrimethylsilane cyanation hydrocyanation; ketone cyanotrimethylsilane; acetal cyanotrimethylsilane; ortho ester cyanotrimethylsilane; sugar cyanotrimethylsilane; nitrile.
Me3SiCN adds to some α,β-unsaturated ketones in a conjugate manner under the catalytic action of Lewis acids such as Et3Al, AlCl3, and SnCl2. Hydrolysis of the products gives β-cyano ketones which are identical to the hydrocyanated products of the starting enones. Me3SiCN reacts with acetals and ortho esters under the catalytic action of SnCl2 or BF3·OEt2 affording 2-alkoxy- and 2,2-dialkoxyalkanenitriles. Application of the reaction to O-protected β-D-ribofuranoses gives selectively β-D-ribofuranosyl cyanide in excellent yield.
Tetrahedron published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Computed Properties of 6136-93-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts