In 2019,Bulletin of the Korean Chemical Society included an article by Chia, Poh Wai; Yong, Fu Siong Julius; Mohamad, Habsah; Kan, Su-Yin. Safety of 4-Fluorobenzonitrile. The article was titled 《Cyanation of Anilines to Aryl Nitriles Using tert-Butyl Isocyanide: A Simple and Copper-free Procedure》. The information in the text is summarized as follows:
In this manuscript, a simple and copper-free procedure for the synthesis of aryl nitrile derivatives from anilines is described. Under the improved protocol, the anilines were reacted with tert-Bu isocyanide under a mild reaction condition without the use of solvents and copper catalyst to synthesize benzonitriles. This copper-free Sandmeyer-type reaction could tolerate a range of anilines bearing different functional groups and also can be conducted even without the exclusion of air. In addition, this method has afforded the aryl nitriles I (R1 = H, 4-Cl, 4-Me, 2-F, etc.) in moderate to good yields (52-81%). The obtained results in this study reveal that the tert-Bu isocyanide as a potential cyanide source for the cyanation reaction. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)
4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Safety of 4-Fluorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts