Application In Synthesis of 2-BromobenzonitrileIn 2019 ,《Tin-Catalyzed Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles: Homogeneous and Heterogeneous Procedures》 was published in Advanced Synthesis & Catalysis. The article was written by Chretien, Jean-Mathieu; Kerric, Gaelle; Zammattio, Francoise; Galland, Nicolas; Paris, Michael; Quintard, Jean-Paul; Le Grognec, Erwan. The article contains the following contents:
5-Substituted 1H-tetrazoles were prepared by cycloadditions of nitriles with Me3SiN3 in the presence of Bu3SnOMe or Bu3SnOEt in DMF or di-Bu ether. The mechanism of the cycloaddition was studied; the kinetics and the effect of substituents on the relative rates of aryl nitrile cycloadditions, the structures of transition states for cycloaddition and their free energies using DFT calculations, and the structures of stannylated and silylated intermediates in the cycloadditions were determined Polystyrene-bound tin alkoxides were prepared and used as catalysts for the cycloaddition of aryl nitriles with Me3SiN3 to give tetrazoles; the products were formed with < 10 ppm tin residues in six of nine cases (with tin residues not determined for the remaining three cases). The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Application In Synthesis of 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Application In Synthesis of 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts