HPLC of Formula: 31938-07-5In 2019 ,《Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Collier, Philip N.; Twin, Heather C.; Knegtel, Ronald M. A.; Boyall, Dean; Brenchley, Guy; Davis, Christopher J.; Keily, Shazia; Mak, Chau; Miller, Andrew; Pierard, Francoise; Settimo, Luca; Bolton, Clare M.; Chiu, Peter; Curnock, Adam; Doyle, Elisabeth; Tanner, Adam J.; Jimenez, Juan-Miguel. The article conveys some information:
PKCθ plays an important role in T cell biol. and is a validated target for a number of disease states. A series of potent and selective PKCθ inhibitors were designed and synthesized starting from a HTS hit compound Cell activity, while initially a challenge to achieve, was built into the series by transforming the nitrile unit of the scaffold into a primary amine, the latter predicted to form a new hydrogen bond to Asp508 near the entrance of the ATP binding site of PKCθ. Significant improvements in physiochem. parameters were observed on introduction of an oxetane group proximal to a primary amine leading to compound I, which demonstrated a reduction of symptoms in a mouse model of multiple sclerosis. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5HPLC of Formula: 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.HPLC of Formula: 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts