《Dual Catalytic Strategy for Forging sp2-sp3 and sp3-sp3 Architectures via β-Scission of Aliphatic Alcohol Derivatives》 was published in Journal of the American Chemical Society in 2020. These research results belong to Cong, Fei; Lv, Xin-Yang; Day, Craig S.; Martin, Ruben. Product Details of 105942-08-3 The article mentions the following:
A dual platform for forging sp2-sp3 and sp3-sp3 carbon bonds via catalytic β-scission of aliphatic alc. derivatives with both aryl and alkyl halides is disclosed [e.g., I + p-(F3C)C6H4Br → II (84%, 77% isolated) in presence of photocatalyst, Hantzsch ester under blue LED irradiation with Ni/(4,4′-di-tert-butyl-2,2′-bipyridyl)]. This protocol is distinguished by its wide substrate scope and broad applicability, even in the context of late-stage functionalization. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3) was used in this study.
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts