《Heteroatom-directed metalation. Lithiation of N-propenylbenzamides and N-propenyl-o-toluamides. Novel routes to ortho-substituted primary benzamide derivatives and N-unsubstituted isoquinolin-1(2H)-ones》 was written by Fisher, Lawrence E.; Muchowski, Joseph M.; Clark, Robin D.. HPLC of Formula: 53005-44-0 And the article was included in Journal of Organic Chemistry on April 24 ,1992. The article conveys some information:
Reaction of N-propenylbenzamides obtained by LDA-induced isomerization of the corresponding N-allylbenzamides with 2 equiv of sec-BuLi or tert-BuLi at low temperature regiospecifically generates the highly reactive N,ortho-dilithiated species. These dilithio species react with numerous electrophilic reagents, including alkyl halides, giving adducts which on hydrolysis with warm 50% aqueous acetic acid are converted into ortho-substituted primary benzmides in excellent yields. ortho-Lithiation of N-propenylbenzamides is thus formally equivalent to ortho-lithiation of primary benzamides. The utility of this synthetic operation is exemplified by the synthesis of 2-methoxy-6-methylbenzoic acid and 2-methoxy-6-methylbenzonitrile from N-propenyl-2-methoxybenzamide. After reading the article, we found that the author used 2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0HPLC of Formula: 53005-44-0)
2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. HPLC of Formula: 53005-44-0 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts