Kaloglu, Murat; Slimani, Ichraf; Ozdemir, Namik; Gurbuz, Nevin; Hamdi, Naceur; Ozdemir, Ismail published an article in 2021. The article was titled 《The direct C(sp2)-H functionalization and coupling of aromatic N-heterocycles with (hetero)aryl bromides by [PdX2(imidazolidin-2-ylidene)(Py)] catalysts》, and you may find the article in Journal of Organometallic Chemistry.Category: nitriles-buliding-blocks The information in the text is summarized as follows:
A series of air- and moisture-stable imidazolidin-2-ylidene-based new palladium complexes with the general formula [PdX2(NHC)(Py)] were synthesized (NHC = N-heterocyclic carbene, Py = pyridine, X = Cl or I). The structures of the palladium complexes were characterized by different techniques such as 1H NMR, 13C NMR, FT-IR spectroscopy and elemental anal. The more detailed structural characterization of one of the palladium complex was determined by single-crystal X-ray diffraction study. The catalytic activities of all palladium complexes were tested in the direct arylation of five-membered aromatic N-heterocycles such as 3,5-dimethylisoxazole and 1-methyl-1H-pyrrole-2-carboxaldehyde with (hetero)aryl bromides in presence of 1 mol% catalyst loading at 120°C. Desired products were obtained in moderate to good yields. In addition to this study using 2-Bromobenzonitrile, there are many other studies that have used 2-Bromobenzonitrile(cas: 2042-37-7Category: nitriles-buliding-blocks) was used in this study.
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts