Kumar, Sunil; Singh, Sohan; Gadwal, Jitendra; Makar, Parvesh; Joshi, Hemant published an article in 2021. The article was titled 《Regioselective C-H arylation of imidazoles employing macrocyclic palladium(II) complex of organoselenium ligand》, and you may find the article in Journal of Organometallic Chemistry.Recommanded Product: 2-Bromobenzonitrile The information in the text is summarized as follows:
In this report, a new air stable bidentate selenium ligand was synthesized by the reaction of 1,8-bis(2-(chloromethyl)phenoxy)octane with sodium salt of phenylselenol. The reaction of this ligand with Pd(CH3CN)2Cl2 in acetonitrile under reflux conditions resulted in 19-membered ring macrocyclic palladium(II) complex. The structure of ligand precursors, ligand, and macrocyclic palladium(II) complex were authenticated by using 1H, 13C{1H} NMR spectroscopy and elemental anal. The obtained air and moisture stable, thermally robust macrocyclic palladium(II) complex was employed as catalyst for regioselective arylation of 1-methylimidazole and 1,2-dimethylimidazole with a variety of aryl bromides. The mild reaction conditions, exclusive C-5 regioselectivity, excellent yields (∼73-95%), low catalyst loading (1.5 mol%) and functional group tolerance are the advantages of this protocol. Homogeneous nature of catalysis process was confirmed with the help of mercury and triphenylphosphine poisoning tests. The catalyst can be recycled and reused with significant loss (22%) in efficiency. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Recommanded Product: 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts