The author of 《Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines》 were Markley, Lowell D.; Tong, Yulan C.; Dulworth, Jacqueline K.; Steward, David L.; Goralski, Christopher T.; Johnston, Howard; Wood, Steven G.; Vinogradoff, Anna P.; Bargar, Thomas M.. And the article was published in Journal of Medicinal Chemistry in 1986. Recommanded Product: 99902-72-4 The author mentioned the following in the article:
Seventy-four title compounds [I; R1 and R2 = e.g. H, 3-, 4-, 5-, or 6-MeSO2, 4-NO2, 2,4-(NO2)2, 4-MeSO2-2-CN, 5-CN, 4-MeO, 4-MeCONH-2-CN, etc.; R3 and R4 = e.g. H, 4-Cl, 3,4-Cl2, 4-COMe, 3,4-(MeO)2, 4-SMe 3-CF3, 4-CN, etc.; and X = CH or N] were prepared, mostly by nucleophilic aromatic substitution reactions of the appropriate phenol with aryl halides with subsequent functional group transformations where necessary, and tested for activity against picornaviruses (rhino- and coxsackie-virus) in vitro; selected I were also tested for protection from coxsackievirus infection in mice. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile [78940-62-2] demonstrated broad-spectrum antipicornavirus activity; this compound and several of its analogs were also effective antiviral agents in vivo. Some structure-activity relations are discussed.6-Phenoxynicotinonitrile(cas: 99902-72-4Recommanded Product: 99902-72-4) was used in this study.
6-Phenoxynicotinonitrile(cas: 99902-72-4) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Recommanded Product: 99902-72-4 Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts