Niknam, Esmaeil; Panahi, Farhad; Khalafi-Nezhad, Ali published an article in 2021. The article was titled 《Immobilized Pd on a NHC-functionalized metal-organic framework MIL-101(Cr): an efficient heterogeneous catalyst in the Heck and copper-free Sonogashira coupling reactions》, and you may find the article in Journal of Organometallic Chemistry.Safety of 4-Bromobenzonitrile The information in the text is summarized as follows:
A heterogeneous palladium catalyst system based on immobilization of palladium moieties on a N-heterocyclic carbene (NHC) modified metal organic framework (MOF) was developed for the Heck and copper-free Sonogashira coupling reactions. In order to prepare this catalyst system, first, MIL-101(Cr) was functionalized with NHC moieties through a post-synthetic modification (PSM) approach, and then Pd metal was stabilized on the prepared MIL-101(Cr)-NHC substrate. This material was characterized using various microscopic and spectroscopic techniques and then was used as an efficient heterogeneous Pd catalyst system in the Heck and copper-free Sonogashira reactions. Results of the heterogeneity tests showed that the Pd-NHC-MIL-101(Cr) catalyst can efficiently catalyzed these coupling reactions heterogeneously and no remarkable changes observed in the morphol. and structure of MIL-101(Cr) template during the reaction progress. Also, existence of palladium nanoparticles immobilized on the MOF structure affirmed by the TEM and XPS anal. confirmed the oxidation state of Pd. A variety of alkene and alkyne derivatives were synthesized in good to excellent yields using this heterogeneous Pd catalyst system under normal conditions. More importantly Pd-NHC-MIL-101(Cr) catalyst was simply recovered from the reaction medium without remarkable decreasing in its catalytic activities after five times of reusability. The ICP anal. showed the very low Pd and Cr metals leaching, representing high stability and applicability of this catalyst in Pd coupling reactions. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzonitrile(cas: 623-00-7Safety of 4-Bromobenzonitrile)
4-Bromobenzonitrile(cas: 623-00-7) has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction.Safety of 4-Bromobenzonitrile It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts