The author of 《A Novel Iron-catalyzed One-pot Synthesis of 3-Amino-1,2,4-triazoles》 were Rohand, Taoufik; Mkpenie, Victor N.; El Haddad, Mohammadine; Marko, Istvan E.. And the article was published in Journal of Heterocyclic Chemistry in 2019. Product Details of 2042-37-7 The author mentioned the following in the article:
A novel one-pot synthesis of 3-amino-1,2,4-triazole developed via iron(III) catalyzed route is reported [e.g., benzonitrile + cyanamide + hydroxylamine hydrochloride → I (81%) in presence of FeCl3, PMe3 and base]. The new method is more efficient, simple, and convenient and presents a concise new strategy for the synthesis of 3-amino-1,2,4-triazole derivatives The iron(III) complex intermediate assisted in the intramol. bond cyclization owing to its Lewis acidity or oxidizing properties. A series of aromatic nitriles bearing different electron-donating and electron-withdrawing groups substituted at para and/or ortho positions were also investigated. The position of the substituents affected the yield of the final compound, with the para-substituted substrates giving relatively higher yields. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Product Details of 2042-37-7)
2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Product Details of 2042-37-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts