Wen, Xiaoting; He, Jingxi; Xi, Hui; Zheng, Qi; Liu, Weiping published an article in 2022. The article was titled 《Hydration of Nitriles Enabled by PNP-manganese Pincer Catalyst》, and you may find the article in Asian Journal of Organic Chemistry.Quality Control of 2-Bromobenzonitrile The information in the text is summarized as follows:
A general and practical methodol. for the hydration of nitriles to primary amides enabled by manganese catalyst was presented. The described protocol showed broad substrate scope with good functional group tolerance, including a wide range of (hetero)aromatic and aliphatic nitriles, thus afforded the corresponding amides RC(O)NH2 [R = c-hexyl, Ph, 2-furyl., etc.] in good to excellent isolated yields under mild conditions. Preliminary mechanistic studies indicated that metal-ligand cooperation (MLC) mode was involved in this catalytic process. In the experiment, the researchers used many compounds, for example, 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Quality Control of 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts