In 2019,European Journal of Medicinal Chemistry included an article by Yu, Jia-Ying; Li, Xue-Qiang; Wei, Meng-Xue. Related Products of 17201-43-3. The article was titled 《Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives》. The information in the text is summarized as follows:
Twelve derivatives of artemisinin-piperazine-dithiocarbamate, I (R = CH2Ph, CH2C6H4Me-4, n-pentyl, CH2CO2CH2Ph, etc.), have been synthesized, and some of them show good in vitro cytotoxic activity. Compound I (R = CH2C6H4CN-4) (II) exhibits the best inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.0025 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 0.18 ± 0.04 μM for 72 h. The results indicate that compound II is more cytotoxic towards cancer cell lines than towards benign cell lines compared with vincristine in vitro. And compound II also has good inhibitory activity against colon, breast and prostate cancer cells. Meanwhile, we have also proposed the six-member ring mechanism of DMSO in catalyzing the esterification of hydroxyl and acyl chloride. Instead of using the hydroxyl, we can obtain the nucleophilic substitution production simply and efficiently without a Lewis acid, which has not been reported previously. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Related Products of 17201-43-3)
4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Related Products of 17201-43-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts