COA of Formula: C7H3BrFNIn 2019 ,《Discovery of novel pan-genotypic HCV NS5A inhibitors containing a novel tetracyclic core》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Yu, Wensheng; Hu, Bin; Zhong, Bin; Hao, Jinglai; Lei, Zhixin; Agrawal, Sony; Rokosz, Laura; Liu, Rong; Chen, Shiying; Asante-Appiah, Ernest; Kozlowski, Joseph A.. The article contains the following contents:
A series of novel tetracyclic core-containing HCV NS5A inhibitors has been discovered. Incorporation of tetrahydropyran-substituted amino acid moiety improved their potency and yielded HCV NS5A inhibitors with a min. potency shift from the GT1a strain compared to other genotypes and mutants. Compounds 53 and 54 showed the best potency profile and had reasonable half-times in rat PK studies. However, further optimization of their oral bioavailability is still needed in order to advance them for further development. [BMCL Abstract] 2000 Elsevier Science Ltd. All rights reserved. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3COA of Formula: C7H3BrFN) was used in this study.
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.COA of Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts