Quality Control of 2-BromobenzonitrileIn 2021 ,《Arylbiamidines: synthesis and structural studies en route to anticancer applications》 was published in New Journal of Chemistry. The article was written by Grytsai, Oleksandr; Goncalves, Leticia Christina Pires; Bardovskyi, Rostyslav; Hamouda-Tekaya, Nedra; Rocchi, Stephane; Ronco, Cyril; Benhida, Rachid. The article contains the following contents:
Biamidines are a unique and poorly studied class of nitrogenous compounds prone to tautomerization and H-bonding. Four series of heteroaryl diarylbiamidines were synthesized and the antimelanoma activity and physicochem. properties of the resulting 37 new compounds were evaluated. The dimethylthiazolyl 3-bromophenyl biamidine derivative B6 (I) inhibits the growth of six different melanoma cell lines, having higher activity than the pos. control drug, the B-RAF inhibitor PLX4032. This study introduces diarylbiamidines as promising frameworks for drug discovery. In addition to this study using 2-Bromobenzonitrile, there are many other studies that have used 2-Bromobenzonitrile(cas: 2042-37-7Quality Control of 2-Bromobenzonitrile) was used in this study.
2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Quality Control of 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts