《Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones》 was published in Chemistry – An Asian Journal in 2020. These research results belong to Zhen, Qianqian; Chen, Lepeng; Qi, Linjun; Hu, Kun; Shao, Yinlin; Li, Renhao; Chen, Jiuxi. Reference of 4-Bromo-2-fluorobenzonitrile The article mentions the following:
The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles R1-2-(NCCH(R2))C6H3CN (R1 = H, 4-Me, 6-Ph, 5-Br, etc.; R2 = H, Ph, thiophen-3-yl, i-Pr, etc.) with arylboronic acids ArB(OH)2 (Ar = Ph, thiophen-3-yl, benzo[d][1,3]dioxol-5-yl, etc.) in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines I (R1 = H, 6-Me, 8-Ph, 7-Br, etc.) with good functional group tolerance under mild conditions. This chem. has also been successfully applied to the synthesis of isoquinolones II by the tandem reaction of Me 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chem. is also indicated by the synthesis of biol. active mols. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Reference of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts