In 2022,Zheng, Yuanqin; Zhou, Yuqiao; Zhang, Yan; Deng, Pengchi; Zhao, Xiaohu; Jiang, Shichao; Du, Guangxi; Shen, Xin; Xie, Xinyu; Su, Zhishan; Yu, Zhipeng published an article in Chemistry – An Asian Journal. The title of the article was 《Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “”Photo-Clicked”” Access to Carbamoyl Formazan Photoswitches In Situ》.Electric Literature of C7H3BrFN The author mentioned the following in the article:
A “”photo-click”” method that involved nitrile imine from diarylsydnone to capture diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD was described. DFT calculation revealed that H-bonding interactions between PTAD and water were vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit anal. (NBO). The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z <-> E photo-switchable linker on target mols., including peptide and drugs, with excellent anti-fatigue performance. This strategy was showcased to construct highly functionalized carbamoyl formazans such as I [R = H, 4-F, 4-Ph, etc.; R1 = 4-CF3, 3-CN, etc.; R2 = H, 4-F, 4-MeO, etc.] in situ for photo-pharmacol. and material studies, which also expanded chem. of PTAD in aqueous media.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Electric Literature of C7H3BrFN) was used in this study.
4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Electric Literature of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts