Mai, Duy N.; Wolfe, John P. published the artcile< Asymmetric Palladium-Catalyzed Carboamination Reactions for the Synthesis of Enantiomerically Enriched 2-(Arylmethyl)- and 2-(Alkenylmethyl)pyrrolidines>, Electric Literature of 6136-93-2, the main research area is pentenylamine asym carboamination bromide aryl alkenyl palladium catalyst; pyrrolidine arylmethyl asym preparation; alkenylmethyl pyrrolidine asym preparation; tylophorine asym preparation.
The enantioselective synthesis of 2-(arylmethyl)- and 2-(alkenylmethyl)pyrrolidine derivatives, e.g., I, via Pd-catalyzed alkene carboamination reactions was described. These transformations generated enantiomerically enriched products with up to 94% ee from readily available alkenyl or aryl bromides and N-Boc-pent-4-enylamines. The application of this method to a concise asym. synthesis of (-)-tylophorine was also discussed.
Journal of the American Chemical Society published new progress about Amination catalysts (stereoselective, intramol., carbo-). 6136-93-2 belongs to class nitriles-buliding-blocks, and the molecular formula is C6H11NO2, Electric Literature of 6136-93-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts