Smith, William J. III; Sawyer, J. Scott published the artcile< A novel and selective method for the N-arylation of indoles mediated by KF/Al2O3>, HPLC of Formula: 94087-40-8, the main research area is regioselective arylation indole potassium fluoride.
Indole was treated with aryl electrophiles in the presence of 37% KF/Al2O3 and catalytic 18-crown-6 in DMSO at 120 °C to give regioselectively 1-arylindoles in fair to excellent yield. Electrophiles containing electronically unfavorable substitution patterns or leaving groups, such as 3-chlorobenzonitrile, coupled effectively under the reaction condition. For example, the potassium-fluoride mediated arylation of 1H-indole with 3-chloro-2-fluorobenzonitrile gave 3-chloro-2-(1H-indol-1-yl)benzonitrile (68% yield).
Tetrahedron Letters published new progress about Arylation, regioselective. 94087-40-8 belongs to class nitriles-buliding-blocks, and the molecular formula is C7H3ClFN, HPLC of Formula: 94087-40-8.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts