Thorarensen, Atli; Wakefield, Brian D.; Romero, Donna L.; Marotti, Keith R.; Sweeney, Michael T.; Zurenko, Gary E.; Rohrer, Douglas C.; Han, Fusen; Bryant, Garold L. published the artcile< Preparation of novel anthranilic acids as antibacterial agents. Extensive evaluation of alternative amide bioisosteres connecting the A- and the B-rings>, Recommanded Product: Methyl 5-cyano-2-methylbenzoate, the main research area is anthranilic acid analog preparation antibacterial.
The identification of an anthranilic acid lead and the optimization resulting in the advanced lead I was recently described. In this report, the preparation of several selected amide bioisosteres connecting the two benzene rings are described. The E-alkene provided a rigid analog with equal potency to the corresponding amide. This indicates that the amide is not a recognition element and rather acts as an appropriate spatial linker of the two important aryl rings. The work here clearly demonstrates that the amide linker can be replaced with several functionalities without significant deterioration in the MIC activity.
Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 103261-68-3 belongs to class nitriles-buliding-blocks, and the molecular formula is C10H9NO2, Recommanded Product: Methyl 5-cyano-2-methylbenzoate.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts