《Copper-Catalyzed Tandem Reactions of 2-Amine-[1,3,5]triazines with Nitriles》 was written by Zhang, Li-Yu; Zhang, Chen; Wang, Tao; Shi, Yu-Long; Ban, Meng-Tao; Cui, Dong-Mei. Recommanded Product: 1194-02-1This research focused ontriazolotriazinamine triazinylbenzamide preparation; copper catalyst oxidative aerobic condensation cyclocondensation reaction triazinamine; tandem reaction triazinamine aryl nitrile acetonitrile copper catalyst; triazinamine oxidative cyclocondensation aryl nitrile copper catalyst; arylacetonitrile oxidative condensation triazinamine arylamine copper catalyst. The article conveys some information:
In the presence of CuCl and ZnCl2, [1,3,5]triazinamines I (R = Me2N, Et2N, 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl; R1 = R2 = H) underwent aerobic oxidative cyclocondensation reactions with aryl nitriles R3CN (R3 = Ph, 4-MeC6H4, 3-MeC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 4-BrC6H4, 3,5-Cl2C6H3, 4-F3CC6H4, 4-NCC6H4, 2-thienyl, 4-pyridinyl) to yield [1,2,4]triazolo[1,5-a][1,3,5]triazinamines II (R = Me2N, Et2N, 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl; R2 = H; R3 = Ph, 4-MeC6H4, 3-MeC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 4-BrC6H4, 3,5-Cl2C6H3, 4-F3CC6H4, 4-NCC6H4, 2-thienyl, 4-pyridinyl). In the presence of CuBr, [1,3,5]triazinamines I (R = Me2N, 1-piperidinyl, H, Ph; R1 = H; R2 = H, Me, Ph), 2-aminopyrimidine, 2-aminopyridine, and aniline underwent oxidative condensation reactions with arylacetonitriles R4CH2CN (R4 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 3-F3CC6H4) to yield N-triazinylamides I (R = Me2N, 1-piperidinyl, H, Ph; R1 = R4; R2 = H, Me, Ph; R4 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 3-F3CC6H4), N-(2-pyrimidinyl)benzamide, N-(2-pyridinyl)benzamide, and N-phenylbenzamide. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1) was used in this study.
4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 1194-02-1
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts