In 2015,He, Wu; Zhou, Bin; Liu, Weijia; Zhang, Meizi; Shen, Zhenhua; Han, Zhifu; Jiang, Qingwei; Yang, Qinghua; Song, Chuanjun; Wang, Ruiyong; Niu, Tianhui; Han, Shengna; Zhang, Lirong; Wu, Jie; Guo, Feima; Zhao, Renbin; Yu, Wenquan; Chai, Jijie; Chang, Junbiao published 《Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)》.Journal of Medicinal Chemistry published the findings.Product Details of 31938-07-5 The information in the text is summarized as follows:
N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide I is found to be an inhibitor of the fat mass and obesity associated protein (FTO). The crystal structure of human FTO with I reveals a novel binding site for the FTO inhibitor and defines the mol. basis for recognition by FTO of the inhibitor. The identification of the new binding site offers new opportunities for further development of selective and potent inhibitors of FTO, which is expected to provide information concerning novel therapeutic targets for treatment of obesity or obesity-associated diseases. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Product Details of 31938-07-5)
2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Product Details of 31938-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts