Schubert, Thomas; Kula, Maria-Regina; Muller, Michael published their research in Synthesis on December 31 ,1999. The article was titled 《Chemoenzymic synthesis of (S)-8-O-methylmellein by Candida parapsilosis carbonyl reductase》.Safety of 2-Methoxy-6-methylbenzonitrile The article contains the following contents:
Screening of various ortho-substituted (2-oxopropyl)benzene derivatives with carbonyl reductases and alc. dehydrogenases, resp., revealed that compounds containing ortho-substituents with only little steric demand are feasible substrates. (S)-8-O-methylmellein was synthesized by stereoselective enzymic reduction of 2-methoxy-6-(2-oxopropyl)benzonitrile with Candida parapsilosis carbonyl reductase as the key step, and completed by a 1-step hydrolysis and intramol. cyclization. After reading the article, we found that the author used 2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0Safety of 2-Methoxy-6-methylbenzonitrile)
2-Methoxy-6-methylbenzonitrile(cas: 53005-44-0) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Safety of 2-Methoxy-6-methylbenzonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts