Shen, Cong; Zhu, Yuhang; Jin, Shuqi; Xu, Kejie; Luo, Shuxin; Xu, Lixia; Zhong, Guofu; Zhong, Liangjun; Zhang, Jian published an article in 2022. The article was titled 《Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol》, and you may find the article in Organic Chemistry Frontiers.Application of 2042-37-7 The information in the text is summarized as follows:
N,N-bidentate-chelation-assisted α- and β-olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzonitrile(cas: 2042-37-7Application of 2042-37-7)
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Application of 2042-37-7
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts