The author of 《Quasi Pd1Ni single-atom surface alloy catalyst enables hydrogenation of nitriles to secondary amines》 were Wang, Hengwei; Luo, Qiquan; Liu, Wei; Lin, Yue; Guan, Qiaoqiao; Zheng, Xusheng; Pan, Haibin; Zhu, Junfa; Sun, Zhihu; Wei, Shiqiang; Yang, Jinlong; Lu, Junling. And the article was published in Nature Communications in 2019. Reference of 4-Fluorobenzonitrile The author mentioned the following in the article:
Hydrogenation of nitriles represents as an atom-economic route to synthesize amines, crucial building blocks in fine chems. However, high redox potentials of nitriles render this approach to produce a mixture of amines, imines and low-value hydrogenolysis byproducts in general. Here we show that quasi at.-dispersion of Pd within the outermost layer of Ni nanoparticles to form a Pd1Ni single-atom surface alloy structure maximizes the Pd utilization and breaks the strong metal-selectivity relations in benzonitrile hydrogenation, by prompting the yield of dibenzylamine drastically from ∼5 to 97% under mild conditions (80°C; 0.6 MPa), and boosting an activity to about eight and four times higher than Pd and Pt standard catalysts, resp. More importantly, the undesired carcinogenic toluene byproduct is completely prohibited, rendering its practical applications, especially in pharmaceutical industry. Such strategy can be extended to a broad scope of nitriles with high yields of secondary amines under mild conditions. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Reference of 4-Fluorobenzonitrile)
4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Reference of 4-Fluorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts