《Cascade synthesis of novel functionalized pyridine-fused coumarins in aqueous medium》 was published in RSC Advances in 2014. These research results belong to Xiang, Haoyue; Chen, Jianyang; Miao, Zehong; Yang, Chunhao. Quality Control of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile The article mentions the following:
A simple, convenient and efficient catalyst-free approach for the synthesis of a novel series of pyridine-fused coumarins, e.g., I, via a cascade reaction from chromone derivatives and Et amidinoacetate in an environmentally friendly aqueous medium was developed. This cascade reaction involves a chemoselective Michael addition-heterocyclization-intramol. cyclization sequence. The experimental part of the paper was very detailed, including the reaction process of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3Quality Control of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile)
6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile(cas: 50743-32-3) belongs to nitriles. Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Quality Control of 6-Isopropyl-4-oxo-4H-chromene-3-carbonitrile Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts