In 2019,Tetrahedron Letters included an article by Yu, Xiaoqiang; Yin, Qing; Zhang, Zhiheng; Huang, Tianyu; Pu, Zichao; Bao, Ming. Formula: C7H4FN. The article was titled 《Synthesis of 2-substituted benzothiazoles via the Bronsted acid catalyzed cyclization of 2-amino thiophenols with nitriles》. The information in the text is summarized as follows:
A convenient and efficient method for the synthesis of 2-substituted benzothiazoles I [R1 = H, 5-Cl; R2 = H, 4-Me, 3-F3C, etc.] from simple and readily available 2-aminothiophenols and nitriles was described. The Bronsted acid-catalyzed cyclization reaction was performed under metal and solvent-free conditions. The low cost of catalyst and simplicity of procedure were advantages of this method. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzonitrile(cas: 1194-02-1Formula: C7H4FN)
4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Formula: C7H4FN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts