Zhu, Chen; Yue, Huifeng; Rueping, Magnus published an article in 2022. The article was titled 《Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry》, and you may find the article in Nature Communications.Name: 2-Bromobenzonitrile The information in the text is summarized as follows:
A three-component, reductive cascade, cross-coupling reaction for the arylalkylation of alkynes was reported. A wide range of trisubstituted alkenes were obtained in good to high yields with excellent chemo- and stereoselectivity by switching between electrochem. and photocatalysis. The E isomer of the product was obtained exclusively when the reaction was conducted with electricity and nickel, while the Z isomer was generated with high stereoselectivity when photo- and nickel dual catalysts were used. Moreover, photo-assisted electrochem. enabled nickel catalyzed protocol was demonstrated to selectively deliver Z-trisubstituted alkenes without the addition of photocatalysts. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)
2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. In addition, 2-bromobenzonitrile can be used for the Suzuki coupling reaction.Name: 2-Bromobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts