On January 15, 2019, Frasson, Ilaria; Spano, Virginia; Di Martino, Simona; Nadai, Matteo; Doria, Filippo; Parrino, Barbara; Carbone, Anna; Cascioferro, Stella Maria; Diana, Patrizia; Cirrincione, Girolamo; Freccero, Mauro; Barraja, Paola; Richter, Sara N.; Montalbano, Alessandra published an article.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines. And the article contained the following:
[1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low micromolar concentrations (EC50 0.01-6.59 μM). The most photocytotoxic derivative showed very high selectivity and photocytotoxicity indexes (SI = 72-86, PTI>5000), along with a triplet excited state with exceptionally long lifetime (18.0 μs) and high molar absorptivity (29781 ± 180 M-1cm-1 at λmax 315 nm). The light-induced production of ROS promptly induced an unquenchable apoptotic process selectively in tumor cells, with mitochondrial and lysosomal involvement. Altogether, these results demonstrate that the most active compound acts as a promising singlet oxygen sensitizer for biol. applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Name: 2-Aminomalononitrile 4-methylbenzenesulfonate
The Article related to triazolo naphthyridine preparation photocytotoxic activity, oxazolo naphthyridine preparation photocytotoxic activity, photochemiotherapy, photosensitizing agents, reactive oxygen species, [1,2,3]triazolo[4,5-h][1,6]naphthyridines, [1,3]oxazolo[5,4-h][1,6]naphthyridines and other aspects.Name: 2-Aminomalononitrile 4-methylbenzenesulfonate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts