Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Related Products of 20099-89-2.
Liu, Jing;Huang, Hong-Li;Wang, Chen;Li, Yinghua;Li, Huaqiang;Hu, Honggang;He, Shipeng;Tang, Hua;Gao, Fei research published 《 Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives》, the research content is summarized as follows. A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazoles had been established with α-carbonyl alkyl bromides. This protocol provided an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones I [R = CH2CO2Et, CH2C(O)Ph, 4-MeC6H4C(O)CH2, etc.; R1 = H, Me, Br; R2 = H, Me, OMe, t-Bu, F; R3 = H, Me, Br; R4 = H, F, Cl, Br; R5 = H, Me, Cl; R6 = H, Me, Cl] in outstanding yields, mild reaction conditions and excellent functional group tolerance.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Related Products of 20099-89-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts