Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Application In Synthesis of 20099-89-2.
Liu, Xiang;Song, Dan;Zhang, Zemin;Lin, Jiatong;Zhuang, Canzhan;Zhan, Haiying;Cao, Hua research published 《 Regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions》, the research content is summarized as follows. An efficient and straightforward metal-free regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizine-dithiocarbamate derivatives, e.g., I (R1 = H, 8-Br, 6-Et, 7-MeO, etc., R2 = Ph, 3,4-Cl2C6H3, 2-furyl, etc.), were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1,2-a]pyridines II (R1 = H, 7-Me, R2 = Ph, 3-FC6H4, 3-MeOC6H4) were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in organic synthesis.
Application In Synthesis of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts