Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Safety of Methyl 2-cyanoacetate.
Mao, Kaimin;Dai, Lei;Chen, Ang;Liu, Yun;Liu, Xiaoqin;Wang, Chang;Rong, Liangce research published 《 Radical Annulation for the Synthesis of Cyclopenta[c]chromene Derivatives》, the research content is summarized as follows. A Cu-catalyzed oxidative radical [2+2+1] annulation reaction of phenol-linked 1,7-enynes with α-active methylene nitrile was described, affording cyclopenta[c]chromene derivatives bearing several functional groups in excellent yields. The wide substrate range, good group tolerance and easy amplification experiments indicated the practicability of this synthesis strategy. This process provided an alternative convenient route for the synthesis of cyclopenta[c]chromene derivatives
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Safety of Methyl 2-cyanoacetate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts