Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. COA of Formula: C4H5NO2.
Mohlala, Reagan Lehlogonolo;Coyanis, Elena Mabel;Fish, Muhammad Qasim;Bode, Moira Leanne research published 《 Synthesis of hexahydroquinoline-3-carboxamide derivatives and their HIV-1 antiviral activity》, the research content is summarized as follows. Computational modeling was used to identify scaffolds with the potential to disrupt the interaction between HIV-1 integrase and lens epithelium-derived growth factor (HIV-1-IN-LEDGF/p75). Virtual screening of com. library collections led to the identification of N-(4-chlorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide as a promising candidate. The synthesis of this compound and its derivatives involved the reaction of the corresponding carboxylic acid derivatives with aniline in the presence of coupling agent carbonyldiimidazole (CDI). This gave rise to N-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxamides in yields of 71-85%. These compounds were found to be non-toxic in an MT4 cell line at 100μM and were subsequently evaluated for antiviral activity in infected MT4 cells at a single dose concentration of 100μM.
COA of Formula: C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts