Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Formula: C9H6BrNO.
Moolman, Chantalle;van der Sluis, Rencia;Beteck, Richard M.;Legoabe, Lesetja J. research published 《 Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors》, the research content is summarized as follows. A series of benzofuran-based compounds I [R1 = H, HO, MeO, Cl; R2 = H, HO, MeO, (5H2C)N; R3 = H, HO, MeO, Br; R4 = H, MeO, Cl; R5 = H, F, NC, MeO, Cl, Br] was synthesized and evaluated as inhibitors of recombinantly expressed and purified PfGSK-3 and human glycogen synthase kinase-3 beta (HsGSK-3β). Of this series, five compounds I [R1 = H; R2 = H, MeO; R3 = H, MeO; R4 =H, MeO, Cl; R5 = H, F, NC, Cl] preferentially inhibited PfGSK-3, with four of these compounds exhibiting IC50 values in the sub-micromolar range (0.00048-0.440μM). Evaluation of the structure-activity relationships required for PfGSK-3 selective inhibition indicated that a C6-OCH3 substitution on ring A was preferred, while the effect of the ring B substituent on activity, in decreasing order was: C4′-CN > C4′-F > C3′-OCH3 > C3′,4′-di-Cl. To date, development of PfGSK-3 inhibitors was limited to the 4-phenylthieno[2,3-b]pyridine class. Chalcone-based scaffolds, such as the benzofurans I described herein, are promising new hits which can be explored for future design of PfGSK-3 selective inhibitors.
20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Formula: C9H6BrNO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts